{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:18:28Z","timestamp":1792919908659,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The outcome of relapsed or refractory (R\/R) T\u2010cell acute lymphoblastic leukemia\/lymphoma (T\u2010ALL\/T\u2010LBL) in adults is poor, with less than 20% of patients surviving at 5\u2009years. Nelarabine is the only drug specifically approved for R\/R T\u2010ALL\/T\u2010LBL, but the information to support its use is based on limited available data. The aim of this observational phase four study was to provide recent additional data on the efficacy and safety of nelarabine in adults with R\/R T\u2010ALL\/T\u2010LBL and to evaluate the feasibility and outcome of allogeneic hematopoietic stem cell transplant (SCT) after salvage with nelarabine therapy. The primary endpoints were overall response rate (ORR) and overall survival (OS). Additional endpoints were safety, SCT rate and post\u2010SCT OS. Between May 2007 and November 2018, 118 patients received nelarabine salvage therapy at 27 Italian hematology sites. The median age was 37\u2009years (range 18\u201074\u2009years), 73% were male, 77 had a diagnosis of T\u2010ALL and 41 of T\u2010LBL, and 65\/118 (55%) had received more than two lines of therapy. The median number of nelarabine cycles was two (range 1\u20104); 43\/118 (36%) patients had complete remission (CR), 16 had partial remission (14%) and 59 (50%) were refractory, with an ORR of 50%. The probability of OS, from the first dose of nelarabine, was 37% at 1 year with a median survival of 8 months. The OS at 1 year was significantly better for the 47 patients (40%) who underwent SCT after nelarabine salvage therapy (58% vs 22%, log\u2010rank\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u2009.001). The probability of OS at 2 and 5\u2009years from SCT was 46% and 38%, respectively. Seventy\u2010five patients (64%) experienced one or more drug\u2010related adverse events (AE). Grade III\u2010IV neurologic toxicities were observed in 9\/118 (8%) of cases and thrombocytopenia or\/and neutropenia (grade III\u2010IV) were reported in 41% and 43% of cases, respectively. In conclusion, this is one of the largest cohorts of adult patients with R\/R T\u2010ALL\/T\u2010LBL treated in real life with nelarabine. Taking into account the poor prognosis of this patient population, nelarabine represents an effective option with an ORR of 50% and a CR rate of 36%. In addition, 40% of cases following nelarabine salvage therapy could undergo SCT with an expected OS at 2 and 5\u2009years of 46% and 38%, respectively. The safety profile of nelarabine was acceptable with only 8% of cases showing grade III\u2010IV neurological AE.\n                  <\/jats:p>","DOI":"10.1002\/ajh.25957","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T18:51:21Z","timestamp":1597085481000},"page":"1466-1472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Nelarabine as salvage therapy and bridge to allogeneic stem cell transplant in 118 adult patients with relapsed\/refractory T\u2010cell acute lymphoblastic leukemia\/lymphoma. A CAMPUS ALL study"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-1310","authenticated-orcid":false,"given":"Anna","family":"Candoni","sequence":"first","affiliation":[{"name":"Clinica Ematologica Azienda Sanitaria Universitaria Integrata di Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-9656","authenticated-orcid":false,"given":"Davide","family":"Lazzarotto","sequence":"additional","affiliation":[{"name":"Clinica Ematologica Azienda Sanitaria Universitaria Integrata di Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3721-5403","authenticated-orcid":false,"given":"Felicetto","family":"Ferrara","sequence":"additional","affiliation":[{"name":"U.O.C. Ematologia  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Curti","sequence":"additional","affiliation":[{"name":"Dipartimento di Oncologia ed Ematologia Policlinico S. Orsola\u2010Malpighi  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-8616","authenticated-orcid":false,"given":"Federico","family":"Lussana","sequence":"additional","affiliation":[{"name":"U.O.C. Ematologia Ospedale di Bergamo ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Papayannidis","sequence":"additional","affiliation":[{"name":"Dipartimento di Oncologia ed Ematologia Policlinico S. Orsola\u2010Malpighi  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-0669","authenticated-orcid":false,"given":"Maria Ilaria","family":"Del Principe","sequence":"additional","affiliation":[{"name":"U.O.C. Ematologia AOU Policlinico Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Clinica Ematologica Universit\u00e0 di Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Mosna","sequence":"additional","affiliation":[{"name":"Ematologia e Centro Trapianto di Midollo Osseo Ospedale Regionale San Maurizio  Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-8912","authenticated-orcid":false,"given":"Mario","family":"Delia","sequence":"additional","affiliation":[{"name":"U.O. 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Ematologia IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Mancini","sequence":"additional","affiliation":[{"name":"Dipartimento di Ematologia e Oncologia Ospedale Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Forghieri","sequence":"additional","affiliation":[{"name":"S.C. 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