{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:50:42Z","timestamp":1773996642150,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are multiple intravenous (IV) iron formulations available, of which several may be administered as single\u2010dose infusions such as low\u2010molecular weight iron dextran (LMWID), ferumoxytol, ferric carboxymaltose, and ferric derisomaltose. However, administration of ferumoxytol as a single\u2010dose infusion is off\u2010label as it is approved as a two\u2010dose series. Previous studies of ferumoxytol alone support the effectiveness and safety of the single\u2010dose regimen, but there is a paucity of data directly comparing single\u2010dose ferumoxytol to other single\u2010dose IV iron formulations. This multicenter cohort study sought to affirm the safety and effectiveness of single\u2010dose ferumoxytol compared to single\u2010dose LMWID. Overall, 906 patients who received single\u2010dose LMWID (n = 439) or ferumoxytol (n = 467) were identified, of whom 351 met criteria for the primary effectiveness endpoint defined as median change in hemoglobin (Hb), hematocrit (Hct), and ferritin 8 to 12\u2009weeks from baseline. All 906 patients were included for the secondary analysis evaluating the incidence of adverse events (AE) and requirement of additional IV iron infusions. Median change in Hb (LMWID 0.5 g\/dL; ferumoxytol 0.8 g\/dL; <jats:italic>P<\/jats:italic> =\u2009.24), Hct (LMWID 1.1%; ferumoxytol 1.25%; <jats:italic>P<\/jats:italic> =\u2009.89), and ferritin (LMWID 87\u2009ng\/dL; ferumoxytol 71\u2009ng\/dL; <jats:italic>P<\/jats:italic> =\u2009.47) was not significantly different between groups. Both groups experienced similar rates of AEs (LMWID 2.3%; ferumoxytol 2.8%; <jats:italic>P<\/jats:italic> =\u2009.63). The LMWID patients more frequently required additional IV iron infusions (LMWID 28.5%; ferumoxtyol 16.1%; <jats:italic>P<\/jats:italic> &lt;\u2009.001). These findings support that single\u2010dose ferumoxytol is effective and safe, and that patients may require fewer additional infusions compared to patients who received LMWID.<\/jats:p>","DOI":"10.1002\/ajh.25995","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T07:25:10Z","timestamp":1600845910000},"page":"1572-1577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A multicenter study evaluating the effectiveness and safety of single\u2010dose low molecular weight iron dextran vs single\u2010dose ferumoxytol for the treatment of iron deficiency"],"prefix":"10.1002","volume":"95","author":[{"given":"Jonathan","family":"Cohen","sequence":"first","affiliation":[{"name":"Pharmacy Services Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpine","family":"Khudanyan","sequence":"additional","affiliation":[{"name":"Oregon Heath &amp; Science University School of Medicine  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Lu","sequence":"additional","affiliation":[{"name":"Pharmacy Services Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Wing","sequence":"additional","affiliation":[{"name":"Pharmacy Services Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Olson","sequence":"additional","affiliation":[{"name":"Division of Hematology, OHSU Knight Cancer Institute Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5790-4700","authenticated-orcid":false,"given":"Thomas","family":"Deloughery","sequence":"additional","affiliation":[{"name":"Division of Hematology, OHSU Knight Cancer Institute Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-5976","authenticated-orcid":false,"given":"Joseph J.","family":"Shatzel","sequence":"additional","affiliation":[{"name":"Division of Hematology, OHSU Knight Cancer Institute Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"Department of Biomedical Engineering Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2016.09.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117383"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12560"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1182\/asheducation-2016.1.57","article-title":"Single\u2010dose intravenous iron for iron deficiency: a new paradigm","volume":"1","author":"Auerbach M","year":"2016","journal-title":"Hematology"},{"key":"e_1_2_9_6_1","unstructured":"Feraheme (ferumoxytol) injection [package insert]. Waltham MA:AMAG Pharmaceuticals Inc.2018."},{"key":"e_1_2_9_7_1","unstructured":"INFeD (iron detran) injection [package insert].Madison NJ: Allergan USA Inc.2018."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25548"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24361"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.06.025"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23534"},{"issue":"22","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1182\/blood.V114.22.4054.4054","article-title":"Rapid (sixty minutes) infusion of one gram of low molecular iron dextran: safety and efficacy profile","volume":"114","author":"Auerbach M","year":"2009","journal-title":"Blood"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25060"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.111492"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"137","article-title":"Prevention and management of acute reactions to intravenous iron in surgical patients","volume":"17","author":"Gomez\u2010Ramirez S","year":"2019","journal-title":"Blood Transfus"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.25995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.25995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.25995","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.25995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T13:16:58Z","timestamp":1693833418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.25995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,12]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/ajh.25995"],"URL":"https:\/\/doi.org\/10.1002\/ajh.25995","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,12]]},"assertion":[{"value":"2020-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}