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We examined in\u2010hospital mortality with intermediate\u2010 compared to prophylactic\u2010dose anticoagulation, and separately with in\u2010hospital aspirin compared to no antiplatelet therapy, in a large, retrospective study of 2785 hospitalized adult COVID\u201019 patients. In this analysis, we established two separate, nested cohorts of patients (a) who received intermediate\u2010 or prophylactic\u2010dose anticoagulation (\u201canticoagulation cohort\u201d, N = 1624), or (b) who were not on home antiplatelet therapy and received either in\u2010hospital aspirin or no antiplatelet therapy (\u201caspirin cohort\u201d, N = 1956). To minimize bias and adjust for confounding factors, we incorporated propensity score matching and multivariable regression utilizing various markers of illness severity and other patient\u2010specific covariates, yielding treatment groups with well\u2010balanced covariates in each cohort. The primary outcome was cumulative incidence of in\u2010hospital death. Among propensity score\u2010matched patients in the anticoagulation cohort (N = 382), in a multivariable regression model, intermediate\u2010 compared to prophylactic\u2010dose anticoagulation was associated with a significantly lower cumulative incidence of in\u2010hospital death (hazard ratio 0.518 [0.308\u20130.872]). Among propensity\u2010score matched patients in the aspirin cohort (N = 638), in a multivariable regression model, in\u2010hospital aspirin compared to no antiplatelet therapy was associated with a significantly lower cumulative incidence of in\u2010hospital death (hazard ratio 0.522 [0.336\u20130.812]). In this propensity score\u2010matched, observational study of COVID\u201019, intermediate\u2010dose anticoagulation and aspirin were each associated with a lower cumulative incidence of in\u2010hospital death.<\/jats:p>","DOI":"10.1002\/ajh.26102","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T15:21:22Z","timestamp":1611242482000},"page":"471-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Intermediate\u2010dose anticoagulation, aspirin, and in\u2010hospital mortality in\n                    <scp>COVID<\/scp>\n                    \u201019: A propensity score\u2010matched analysis"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4306-5061","authenticated-orcid":false,"given":"Matthew L.","family":"Meizlish","sequence":"first","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut 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