{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:59:18Z","timestamp":1791896358503,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early T\u2010cell precursor acute lymphoblastic leukemia\/lymphoma (ETP\u2010ALL\/LBL) is characterized by a distinct immunophenotype (CD1a\u2010negative, CD8\u2010negative, CD5\u2010negative or weak\u2010positive &lt;75%, myeloid\/stem\u2010cell markers positive) and poor clinical outcomes. Near\u2010ETP ALL is transcriptionally similar to ETP\u2010ALL but CD5 expression level is not low enough to meet the criteria of ETP immunophenotype. Outcomes of near\u2010ETP ALL are not well characterized. We reviewed 171 patients with newly\u2010diagnosed T\u2010ALL\/LBL. Patients were categorized into three groups; ETP (<jats:italic>N<\/jats:italic> = 27), near\u2010ETP (<jats:italic>N<\/jats:italic> = 24), and non\u2010ETP ALL\/LBL (<jats:italic>N<\/jats:italic> = 120). ETP\u2010ALL\/LBL was associated with a significantly worse survival compared with non\u2010ETP ALL\/LBL: 5\u2010year overall survival (OS) rates 32% versus 63% (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Outcome was similar between near\u2010ETP and non\u2010ETP ALL\/LBL: 5\u2010year OS rates 56% versus 63% (<jats:italic>p<\/jats:italic> = .543). Landmark analysis showed that allogeneic stem cell transplant (allo\u2010SCT) in first remission was beneficial in ETP\u2010ALL\/LBL (5\u2010year event\u2010free survival rates 36% versus 18%, <jats:italic>p<\/jats:italic> = .030) but not in near\u2010ETP or non\u2010ETP ALL\/LBL. Multivariate analysis selected the following as significant independent prognostic factors for OS: age\u2009\u2265\u200960\u2009years (HR 3.11; <jats:italic>p<\/jats:italic> = .003); elevated WBC \u2265100\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L (HR 2.60; <jats:italic>p<\/jats:italic> = .005); and ETP immunophenotype (HR 2.29; <jats:italic>p<\/jats:italic> = .010). A survival advantage with adding nelarabine to hyper\u2010CVAD was observed in non\u2010ETP ALL (5\u2010year OS rates 83% versus 38% with hyper\u2010CVAD plus neralabine versus hyper\u2010CVAD, <jats:italic>p<\/jats:italic> = .003). In conclusion, outcome of ETP\u2010ALL\/LBL was poor and improved with allo\u2010SCT; outcome of near\u2010ETP ALL\/LBL was similar to non\u2010ETP ALL\/LBL; the addition of nelarabine to hyper\u2010CVAD improved the survival in non\u2010ETP ALL only.<\/jats:p>","DOI":"10.1002\/ajh.26144","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T18:40:13Z","timestamp":1614451213000},"page":"589-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Outcome of T\u2010cell acute lymphoblastic leukemia\/lymphoma: Focus on <scp>near\u2010ETP<\/scp> phenotype and differential impact of nelarabine"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0407-1565","authenticated-orcid":false,"given":"Kiyomi","family":"Morita","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston 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