{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:57:08Z","timestamp":1789563428438,"version":"build-2803163510"},"reference-count":114,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:00:00Z","timestamp":1620950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The role of iron in the formation and functioning of erythrocytes, and to a lesser degree of white blood cells, is well established, but the relationship between iron and platelets is less documented. Physiologically, iron plays an important role in hematopoiesis, including thrombopoiesis; iron levels direct, together with genetic factors, the lineage commitment of megakaryocytic\/erythroid progenitors toward either megakaryocyte or erythroid progenitors. Megakaryocytic iron contributes to cellular machinery, especially energy production in platelet mitochondria. Thrombocytosis, possibly favoring vascular thrombosis, is a classical feature observed with abnormally low total body iron stores (mainly due to blood losses or decreased duodenal iron intake), but thrombocytopenia can also occur in severe iron deficiency anemia. Iron sequestration, as seen in inflammatory conditions, can be associated with early thrombocytopenia due to platelet consumption and followed by reactive replenishment of the platelet pool with possibility of thrombocytosis. Iron overload of genetic origin (hemochromatosis), despite expected mitochondrial damage related to ferroptosis, has not been reported to cause thrombocytopenia (except in case of high degree of hepatic fibrosis), and iron\u2010related alteration of platelet function is still a matter of debate. In acquired iron overload (of transfusional and\/or dyserythropoiesis origin), quantitative or qualitative platelet changes are difficult to attribute to iron alone due to the interference of the underlying hematological conditions; likewise, hematological improvement, including increased blood platelet counts, observed under iron oral chelation is likely to reflect mechanisms other than the sole beneficial impact of iron depletion.<\/jats:p>","DOI":"10.1002\/ajh.26189","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T16:50:30Z","timestamp":1618246230000},"page":"1008-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Iron and platelets: A subtle, under\u2010recognized relationship"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-418X","authenticated-orcid":false,"given":"Eolia","family":"Brissot","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire, H\u00f4pital Saint Antoine APHP Paris France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ. Paris 06, Centre de recherche Saint\u2010Antoine, UMR\u2010S938 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2668-9670","authenticated-orcid":false,"given":"Marie\u2010B\u00e9reng\u00e8re","family":"Troadec","sequence":"additional","affiliation":[{"name":"Univ Brest, Inserm, EFS, UMR 1078, GGB Brest France"},{"name":"Service de g\u00e9n\u00e9tique, laboratoire de g\u00e9n\u00e9tique chromosomique CHRU Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-3766","authenticated-orcid":false,"given":"Olivier","family":"Lor\u00e9al","sequence":"additional","affiliation":[{"name":"Inserm, University of Rennes1, UMR 1241, Inrae, NuMeCan Institute Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0045-331X","authenticated-orcid":false,"given":"Pierre","family":"Brissot","sequence":"additional","affiliation":[{"name":"Inserm, University of Rennes1, UMR 1241, Inrae, NuMeCan Institute Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.232124"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.100617"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20191101"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.244731"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-08-743229"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-569129"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-416594"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology9100343"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0110-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.548631"},{"issue":"1","key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/ATVBAHA.120.314645","article-title":"Role of platelets in detection and regulation of infection","volume":"41","author":"Portier I","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144866"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.08.021"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20120327"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01590"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-01003-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314980"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-088500"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-607945"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23682"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10659"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2013.02.006"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002039"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003022"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/75534"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1416"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-596254"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.010535"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2017.09.002"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00153"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.12.026"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.01.007"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(99)00088-2"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.009"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph12030132"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2016.1268047"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202050202"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00029.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.224899"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-387308"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249713"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.09.008"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.10.413"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118135"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008923200"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151179498"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2019.306407"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2020.1366"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305317"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13881"},{"issue":"4","key":"e_1_2_7_52_1","first-page":"1","article-title":"R\u00e9gulation de l'absorption digestive du fer","volume":"35","author":"Brissot PBE","year":"2020","journal-title":"EMC\u2010H\u00e9patologie."},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32594-0"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2018.06.003"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12454"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537100903137306"},{"issue":"3","key":"e_1_2_7_57_1","first-page":"398","article-title":"Platelet parameters in women with iron deficiency anemia","volume":"98","author":"Kadikoylu G","year":"2006","journal-title":"J Natl Med Assoc."},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25925"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2018.1439679"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.245092"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000249"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316453"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018018465"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2199-5"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2015.1010504"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03757-0"},{"issue":"4","key":"e_1_2_7_67_1","first-page":"433","article-title":"Usefulness of immature platelet fraction measurement for diagnosis and monitoring of iron deficiency associated thrombocytopenia","volume":"78","author":"Blandini\u00e8res AAJ\u2010B","year":"2020","journal-title":"Ann Biol Clin (Paris)."},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2019.1678118"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113737"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2014.04.005"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420945"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17252"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3269"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13549"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.07.007"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2720"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2018.53.3.233"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318281f4db"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i12.3180"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.14093"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3872-5"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-019-0664-4"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.04.052"},{"key":"e_1_2_7_85_1","doi-asserted-by":"crossref","first-page":"145293","DOI":"10.1155\/2015\/145293","article-title":"Pathogenesis of Myeloproliferative neoplasms: role and mechanisms of chronic inflammation","volume":"2015","author":"Hermouet S","year":"2015","journal-title":"Mediators Inflamm."},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3701-1"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-01-757930"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.16"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2016.11.008"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22925"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16176"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2011.634933"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1681061"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110116"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80079-7"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.24.3118"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.8b00458"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.246488"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-815928"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2014.04.003"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31550"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22602"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2018.046"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01137"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107653"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355817"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000287"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12507"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.048546"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2341-z"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.07.006"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-2985-y"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.016824"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01131.x"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41397-020-0154-5"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26189","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.26189","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T01:17:27Z","timestamp":1724807847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.26189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,14]]},"references-count":114,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/ajh.26189"],"URL":"https:\/\/doi.org\/10.1002\/ajh.26189","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,14]]},"assertion":[{"value":"2021-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}