{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:55:17Z","timestamp":1787496917079,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Combinations of the BCL\u20102 inhibitor, venetoclax, with either hypomethylating agents (HMA) or low dose cytarabine (LDAC), have shown promising results in clinical trials of AML patients unfit for intensive therapy. We report on the efficacy and safety of venetoclax combinations in AML patients treated outside of clinical trials. Complete remission (CR)\u2009+\u2009CR with incomplete count recovery (CRi) were achieved in 61% of patients, with similar CR+CRi rates in with secondary AML, and in patients who were previously treated with HMA (61% and 43%, respectively). Relapse occurred in 25% of patients, with a median event\u2010free survival (EFS) of 11.7 months (95% CI, 10.09\u201313.35) in responding patients. At a median follow up of 8.7 months, the median overall survival (OS) was 9.8 months (95% CI 6.42\u201313.3) in the entire cohort. In multivariate analysis adverse karyotype was the only negative predictor of CR\/CRi (\n                    <jats:italic>p<\/jats:italic>\n                    =\u2009.03), while both ECOG performance status (PS) and adverse karyotype were significantly associated with shorter OS (\n                    <jats:italic>p<\/jats:italic>\n                    =\u2009.023 and .038, respectively). Median OS was higher in patients achieving CR\/CRi and in patients proceeding to allogeneic stem cell transplantation (allo\u2010SCT). Treatment was well tolerated, with side effects similar to those described in the randomized clinical trials. Tumor lysis syndrome (TLS) occurred in 12% of patients. Our data support the efficacy and safety of venetoclax combinations in newly diagnosed AML patients not eligible for intensive therapy. According to our data, secondary AML patients could benefit from venetoclax combinations similarly to de\u2010novo AML patients, and allo\u2010SCT could be offered to selected patients achieving CR\/CRi.\n                  <\/jats:p>","DOI":"10.1002\/ajh.26190","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T17:03:25Z","timestamp":1617987805000},"page":"790-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Venetoclax combinations induce high response rates in newly diagnosed acute myeloid leukemia patients ineligible for intensive chemotherapy in routine practice"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6269-9994","authenticated-orcid":false,"given":"Arie","family":"Apel","sequence":"first","affiliation":[{"name":"Department of Hematology, Shamir Medical Center (formerly Assaf Harofe Medical Center), Zerifin, Israel, Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakir","family":"Moshe","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Tel\u2010Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5521-1337","authenticated-orcid":false,"given":"Yishai","family":"Ofran","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gural","sequence":"additional","affiliation":[{"name":"Leukemia Service, Department of Hematology Hasassah\u2010Hebrew\u2010University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-0707","authenticated-orcid":false,"given":"Ofir","family":"Wolach","sequence":"additional","affiliation":[{"name":"Institute of Hematology Davidoff Cancer Center, Belinson Hospital, Rabin Medical Center  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1722-4807","authenticated-orcid":false,"given":"Chezi","family":"Ganzel","sequence":"additional","affiliation":[{"name":"Department of Hematology Shaare Zedek Medical Center  Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5294-3524","authenticated-orcid":false,"given":"Jonathan","family":"Canaani","sequence":"additional","affiliation":[{"name":"Hematology Division, Chaim Sheba Medical Center Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miri","family":"Zektser","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Faculty of Health Science Soroka University Medical Center  Beersheba Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Duek","sequence":"additional","affiliation":[{"name":"Hematology Department Assuta Medical Center  Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galia","family":"Stemer","sequence":"additional","affiliation":[{"name":"Hematology Unit Haemek Medical Center  Afula 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Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Koren\u2010Michowitz","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shamir Medical Center (formerly Assaf Harofe Medical Center), Zerifin, Israel, Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 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