{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:59:31Z","timestamp":1792245571634,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We evaluated the outcome of 65 French patients with Extranodal NK\/T\u2010cell lymphoma, nasal type (ENKTL) undergoing hematopoietic stem cell transplantation (HSCT) (19 allogeneic and 46 autologous). Fifty\u2010four patients (83%), most of which receiving L\u2010asparaginase (L\u2010aspa) containing regimens (81%), achieved complete or partial response at time of HCST. After a median follow\u2010up of 79.9\u00a0months, 4\u2010years progression\u2010free survival (PFS) and overall survival (OS) were similar in both autologous and allogeneic groups (PFS: 34% vs. 26%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.12 and OS: 52% vs. 53%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.74). Response status at HSCT was the major independent prognostic factor on survival (OS: HR: 4.013 [1.137; 14.16],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.031 and PFS: HR: 5.231 [1.625; 16.838],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.006). As compared to control patients receiving chemotherapy and\/or radiotherapy containing regimens only, upfront HSCT did not improve the outcome of responder patients, including those treated by L\u2010aspa. However, it tends to provide survival benefit for relapsed patients with initial high\u2010risk clinical features who achieved second remission. Whereas the place of HSCT in upfront therapy has still to be clarified, these data confirm that HSCT should be considered for consolidation in selected patients with relapsed ENKTL. Based on a large non Asian ENKTL cohort since the L\u2010aspa era, this study provides some insight into the survival patterns of ENKTL patients with HSCT in the Western hemisphere and may give future direction for the next clinical trial design.\n                  <\/jats:p>","DOI":"10.1002\/ajh.26200","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T13:55:06Z","timestamp":1618667706000},"page":"834-845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Outcome after hematopoietic stem cell transplantation in patients with extranodal natural killer\/\n                    <scp>T\u2010Cell<\/scp>\n                    lymphoma, nasal type: A French study from the Soci\u00e9t\u00e9 Francophone de Greffe de Moelle et de Th\u00e9rapie Cellulaire (\n                    <scp>SFGM\u2010TC<\/scp>\n                    )"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-2610","authenticated-orcid":false,"given":"Laure","family":"Philippe Walter","sequence":"first","affiliation":[{"name":"Department of Hematology CHV Andr\u00e9 Mignot  le chesnay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Couronn\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics, Necker Hospital, AP\u2010HP, Inserm U1163, IMAGINE Institute Paris University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Jais","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Paris University, Necker Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phong\u2010Dinh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Paris University, Necker Hospital  Paris 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