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Notably, a severe deficiency of ADAMTS13 characterizes TTP (thrombotic thrombocytopenic purpura), a rare but potentially fatal disorder associated with thrombosis due to accumulation of prothrombotic ultra\u2010large VWF multimers. Although prompt identification\/exclusion of TTP can be facilitated by rapid ADAMTS13 testing, the most commonly utilized assays are based on ELISA (enzyme linked immunosorbent assay) and require long turnaround time and have relatively limited throughput. Nevertheless, several rapid ADAMTS13 assays are now available, at least in select geographies. The current mini\u2010review discusses these issues, as well as the potential utility of ADAMTS13 testing in a range of other conditions, including coronavirus disease 2019 (COVID\u201019).<\/jats:p>","DOI":"10.1002\/ajh.26241","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T11:32:45Z","timestamp":1621078365000},"page":"1049-1055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Laboratory testing for\n                    <scp>ADAMTS13<\/scp>\n                    : Utility for\n                    <scp>TTP<\/scp>\n                    diagnosis\/exclusion and beyond"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2103-1661","authenticated-orcid":false,"given":"Emmanuel J.","family":"Favaloro","sequence":"first","affiliation":[{"name":"Department of Haematology Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health 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