{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:09:40Z","timestamp":1788174580620,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic lymphocytic leukemia (CLL)\u2010related symptoms impair the well\u2010being of patients, making improvement of health\u2010related quality of life (QoL) a goal of treatment. The CLL14 trial demonstrated higher efficacy of fixed\u2010duration venetoclax\u2010obinutuzumab (Ven\u2010Obi) compared to chlorambucil\u2010obinutuzumab (Clb\u2010Obi) in patients with previously untreated CLL. To assess patients' QoL, the following patient\u2010reported outcomes (PRO) measures were assessed: the M.D. Anderson Symptom Inventory (MDASI) core instrument and CLL module and the EORTC Quality of Life Questionnaire Core 30 (EORTC QLQ\u2010C30). At treatment start, physical functioning (mean 75.9 [standard deviation (SD)\u2009\u00b1\u200920.1] in the Clb\u2010Obi arm and 76.9 [\u00b119.4] in the Ven\u2010Obi arm), role functioning (73.6 [\u00b127.86] and 72.6 [\u00b126.9]) and GHS\/QoL (63.6 [\u00b121.0] and 60.3 [\u00b120.5]) were comparable between treatment arms per EORTC QLQ\u2010C30 scale scores. Baseline levels of physical and role functioning were maintained throughout treatment and follow\u2010up, with no relevant improvement or deterioration. On average, patients treated with Ven\u2010Obi showed a meaningful improvement of GHS\/QoL during treatment and follow\u2010up by at least eight points at cycle three, whereas improvement was delayed until cycle eight with Clb\u2010Obi. According to MDASI scores, CLL symptoms (1.5 [\u00b11.2] and 1.6 [\u00b11.3]), core cancer symptoms (1.5 [\u00b11.4] and 1.8 [\u00b11.7]) and symptom interference (2.1 [\u00b12.3] and 2.3 [\u00b12.3]) were generally low and comparable between treatment arms at baseline and were maintained throughout treatment and follow\u2010up. This analysis demonstrates that the higher efficacy of Ven\u2010Obi is not associated with QoL impairment and that Ven\u2010Obi achieves early relief of CLL\u2010related symptoms in elderly unfit patients.<\/jats:p>","DOI":"10.1002\/ajh.26260","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T06:33:37Z","timestamp":1622529217000},"page":"1112-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Health\u2010related quality of life with fixed\u2010duration venetoclax\u2010obinutuzumab for previously untreated chronic lymphocytic leukemia: Results from the randomized, phase 3 <scp>CLL14<\/scp> trial"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-0570","authenticated-orcid":false,"given":"Othman","family":"Al\u2010Sawaf","sequence":"first","affiliation":[{"name":"Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf; German CLL Study Group University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Gentile","sequence":"additional","affiliation":[{"name":"Genentech Inc  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Devine","sequence":"additional","affiliation":[{"name":"Genentech Inc  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf; German CLL Study Group University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Sail","sequence":"additional","affiliation":[{"name":"AbbVie Inc.  North Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maneesh","family":"Tandon","sequence":"additional","affiliation":[{"name":"Roche Products Limited  Welwyn Garden City UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Maria","family":"Fink","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf; German CLL Study Group University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Kutsch","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf; German CLL Study Group University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens\u2010Martin","family":"Wendtner","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine Klinikum Schwabing  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Eichhorst","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf; German CLL Study Group University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hallek","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf; German CLL Study Group University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf; German CLL Study Group University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313984"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.170480"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1815281"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30443-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00233.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2790-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.02.059"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119468868.ch31"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv181"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.153"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.03.025"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0602-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.238808"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000336"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30262-2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13503"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-117127"},{"key":"e_1_2_9_19_1","unstructured":"WierdaW SailK NoeL et al.Impact of venetoclax on the quality of life of patients with relapsed\/refrecatory chronic lymphocytic leukemia: results of a phase 2 open\u2010label study of venetoclax (ABT\u2010199\/GDC\u20100199) monotherapy. In:EHA Annual Meeting. Madrid; 2017."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802688517"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806398"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31957"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06791.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.26260","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:40:00Z","timestamp":1693140000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.26260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/ajh.26260"],"URL":"https:\/\/doi.org\/10.1002\/ajh.26260","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,22]]},"assertion":[{"value":"2021-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}