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Compared with Vd, XVd was associated with significant improvements in median progression\u2010free survival (PFS), overall response rate (ORR), and lower rates of peripheral neuropathy, with trends in overall survival (OS) favoring XVd. In BOSTON, 141 (35.1%) patients had MM with high\u2010risk (presence of del[17p], t[4;14], t[14;16], or \u22654 copies of amp1q21) cytogenetics (XVd, <jats:italic>n<\/jats:italic>\u00a0=\u00a070; Vd, <jats:italic>n<\/jats:italic>\u00a0=\u00a071), and 261 (64.9%) exhibited standard\u2010risk cytogenetics (XVd, <jats:italic>n<\/jats:italic>\u00a0=\u00a0125; Vd, <jats:italic>n<\/jats:italic>\u00a0=\u00a0136). Among patients with high\u2010risk MM, median PFS was 12.91\u2009months for XVd and 8.61\u2009months for Vd (HR, 0.73 [95% CI, (0.4673, 1.1406)], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.082), and ORRs were 78.6% and 57.7%, respectively (OR 2.68; <jats:italic>p<\/jats:italic>\u00a0=\u20090.004). In the standard\u2010risk subgroup, median PFS was 16.62\u2009months for XVd and 9.46\u2009months for Vd (HR 0.61; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004), and ORRs were 75.2% and 64.7%, respectively (OR 1.65; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.033). The safety profiles of XVd and Vd in both subgroups were consistent with the overall population. These data suggest that selinexor can confer benefits to patients with MM regardless of cytogenetic risk. ClinicalTrials.gov identifier: NCT03110562.<\/jats:p>","DOI":"10.1002\/ajh.26261","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T02:31:21Z","timestamp":1622601081000},"page":"1120-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Selinexor, bortezomib, and dexamethasone versus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by cytogenetic risk"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0274-4292","authenticated-orcid":false,"given":"Shambavi","family":"Richard","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Tisch Cancer Institute  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajai","family":"Chari","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Tisch Cancer Institute  New York New 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