{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:56:47Z","timestamp":1778637407829,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple myeloma (MM) remains an incurable disease despite incorporation of novel agents. Venetoclax, a B\u2010cell lymphoma 2 (BCL\u20102) inhibitor is approved for some hematologic malignancies but not yet for MM, although clinical trials have shown efficacy in patients with MM, particularly those harboring t(11;14). We reviewed the medical records of relapsed and\/or refractory MM patients to study the efficacy and safety of venetoclax used outside of clinical trials at Mayo Clinic between December, 2016 and March, 2019. The data cut\u2010off date was August 06, 2020. We identified 56 patients of whom 42 (75%) harbored t(11;14). The median number of prior therapies was six (range 1\u201315) and 14% of patients had received \u226510 prior lines of therapy. Fifty\u2010three (95%) patients were refractory to an immunomodulatory drug and proteasome inhibitor. Venetoclax was used as monotherapy or doublet, in combination with dexamethasone in 55% (n\u00a0=\u00a031) and a triplet or quadruplet in 45% of patients. No patient experienced tumor lysis syndrome. Overall response rate in 52 evaluable patients was 44%. The median time to best response was 2\u00a0months and median duration of response was 13.6\u00a0months. The median PFS for the entire cohort was 5.8 (95% CI 4.9\u201310.3) months and median OS was 28.4 (95% CI 14.6\u2010not reached) months. The presence of t(11;14) was associated with improved PFS (median 9.7\u00a0months vs. 4.2\u00a0months, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.019) and OS (median not reached vs. 10.8 9\u00a0months, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.015). Venetoclax demonstrates encouraging activity in heavily\u2010treated patients with relapsed\/refractory MM, particularly the t(11;14) patient\u2010population.<\/jats:p>","DOI":"10.1002\/ajh.26269","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T15:15:11Z","timestamp":1623424511000},"page":"1131-1136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Venetoclax for the treatment of multiple myeloma: Outcomes outside of clinical trials"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-3853","authenticated-orcid":false,"given":"M. Hasib","family":"Sidiqi","sequence":"first","affiliation":[{"name":"Haematology Department Fiona Stanley Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1111-556X","authenticated-orcid":false,"given":"Abdullah S.","family":"Al Saleh","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud Bin Abdulaziz University for Health Sciences  Riyadh Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Riyadh Saudi Arabia"},{"name":"Division of Haematology and HSCT, Department of Oncology King Abdul Aziz Medical City, Ministry of National Guard\u2010Health Affairs  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5392-9284","authenticated-orcid":false,"given":"Shaji K.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5651-1411","authenticated-orcid":false,"given":"Nelson","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Nephrology, Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Jevremovic","sequence":"additional","affiliation":[{"name":"Division of Hematopathology Mayo Clinic Rochester  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2210-2174","authenticated-orcid":false,"given":"Eli","family":"Muchtar","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Mayo Clinic  Rochester Minnesota 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