{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:06:33Z","timestamp":1789013193686,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study sought to link cardiac phenotypes in homozygous Sickle Cell Disease (SCD) patients with clinical profiles and outcomes using cluster analysis. We analyzed data of 379 patients included in the French Etendard Cohort. A cluster analyses was performed based on echocardiographic variables, and the association between clusters, clinical profiles and outcomes was assessed. Three clusters were identified. Cluster 1 (n\u00a0=\u00a0123) patients had the lowest cardiac output, mild left cardiac cavities remodeling, mild diastolic dysfunction, and higher tricuspid regurgitation velocity (TRV). They were predominantly female and displayed the most altered functional limitation. Cluster 2 (n\u00a0=\u00a0102) patients had the highest cardiac output and the most remodeled cardiac cavities. Diastolic function and TRV were similar to cluster 1. These patients had a higher blood pressure and a severe hemolytic anemia. Cluster 3 (n\u00a0=\u00a0154) patients had mild left cardiac cavities remodeling, normal diastolic function and lowest TRV values. They were younger with the highest hemoglobin value. Right heart catheterization was performed in 94 patients. Cluster 1 (n\u00a0=\u00a033) included the majority of pre\u2010capillary PH whilst cluster 2 (n\u00a0=\u00a034) included post\u2010capillary PH. No PH was found in cluster 3 (n\u00a0=\u00a027). After a follow\u2010up of 11.4\u2009\u00b1\u20092\u2009years, death occurred in 41 patients (11%). Cluster 2 patients had the worst prognosis with a 19% mortality rate versus 12% in cluster 1 and 5% in cluster 3 (<jats:italic>p<\/jats:italic> log\u2010rank\u00a0=\u00a00.003). Cluster analysis of echocardiography variables identified three hemodynamic and clinical phenotypes among SCD patients, each predicting a different prognosis.<\/jats:p>","DOI":"10.1002\/ajh.26271","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T14:01:36Z","timestamp":1624024896000},"page":"1166-1175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cardiovascular phenotypes predict clinical outcomes in sickle cell disease: An echocardiography\u2010based cluster analysis"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-0962","authenticated-orcid":false,"given":"Thomas","family":"d'Humi\u00e8res","sequence":"first","affiliation":[{"name":"Physiology Department, FHU SENEC, Henri Mondor Hospital, Assistance Publique H\u00f4pitaux de Paris  Cr\u00e9teil France"},{"name":"INSERM IMRB U955, Team 8, Universit\u00e9 Paris Est (UPEC)  Cr\u00e9teil France"},{"name":"Sickle Cell Referral Center \u2013 UMGGR, Plateforme d'expertise Maladies Rares Grand Paris Est, UPEC, FHU SENEC, CHU Henri Mondor APHP  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Savale","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center H\u00f4pital Bic\u00eatre, Assistance Publique H\u00f4pitaux de Paris  Le Kremlin\u2010Bic\u00eatre France"},{"name":"Universit\u00e9 Paris\u2010Saclay, School of Medicine  Le Kremlin\u2010Bic\u00eatre France"},{"name":"INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies H\u00f4pital Marie Lannelongue  Le Plessis\u2010Robinson 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