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For patients with disease limited to the skin, expectant management or skin\u2010directed therapies is preferred, as both disease\u2010specific and overall survival for these patients is favorable. In contrast, patients with advanced\u2010stage disease with significant nodal, visceral or blood involvement are generally approached with systemic therapies, including biologic\u2010response modifiers, histone deacetylase inhibitors, or antibody\u2010based strategies, in an escalating fashion. In highly\u2010selected patients, allogeneic stem\u2010cell transplantation may be considered, as this may be curative in some patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajh.26299","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T10:45:12Z","timestamp":1627037112000},"page":"1313-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Cutaneous T\u2010cell lymphomas: 2021 update on diagnosis, risk\u2010stratification, and management"],"prefix":"10.1002","volume":"96","author":[{"given":"Alexandra C.","family":"Hristov","sequence":"first","affiliation":[{"name":"Departments of Pathology and Dermatology North Campus Research Complex Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trilokraj","family":"Tejasvi","sequence":"additional","affiliation":[{"name":"Director Cutaneous Lymphoma program, Department of Dermatology A. Alfred Taubman Health Care Center Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-0760","authenticated-orcid":false,"given":"Ryan","family":"A. 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