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However, the risk factors and a method to predict the prognosis of post\u2010transplantation CNS IIDDs are not available. This retrospective study first reviewed data from 4532 patients who received haplo\u2010HSCT during 2008\u20132019 in our center, and 184 patients (4.1%) with IIDDs after haplo\u2010HSCT were identified. Grades II to IV acute graft\u2010versus\u2010host disease (aGVHD) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and chronic GVHD (cGVHD) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.009) were identified as risk factors for developing IIDDs after haplo\u2010HSCT. We then divided the 184 IIDD patients into a derivation cohort and validation cohort due to transplantation time to develop and validate a model for predicting the prognosis of IIDDs. In the multivariate analysis of the derivation cohort, four candidate predictors were entered into the final prognostic model: cytomegalovirus (CMV) infection, Epstein\u2013Barr virus (EBV) infection, IgG synthesis (IgG\u2010syn) and spinal cord lesions. The prognostic model had an area under the receiver operating characteristic curve of 0.864 (95% CI: 0.803\u20130.925) in the internal validation cohort and 0.871 (95% CI: 0.806\u20130.931) in the external validation cohort. The calibration plots showed a high agreement between the predicted and observed outcomes. Decision curve analysis indicated that IIDD patients could benefit from the clinical application of the prognostic model. The identification of IIDD patients after allo\u2010HSCT who have a poor prognosis might allow timely treatment and improve patient survival and outcomes.<\/jats:p>","DOI":"10.1002\/ajh.26312","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T07:44:38Z","timestamp":1628149478000},"page":"1407-1419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical risk factors and prognostic model for idiopathic inflammatory demyelinating diseases after haploidentical hematopoietic stem cell transplantation in patients with hematological malignancies"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1570-7207","authenticated-orcid":false,"given":"Rui\u2010Xin","family":"Deng","sequence":"first","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing China"},{"name":"Collaborative Innovation Center of 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Hematology Peking University Beijing China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing China"},{"name":"National Clinical Research Center for Hematologic Disease Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-7827","authenticated-orcid":false,"given":"Kai\u2010Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing China"},{"name":"Collaborative Innovation Center of Hematology Peking University Beijing China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing China"},{"name":"National Clinical Research Center for Hematologic Disease Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University 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