{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:05:06Z","timestamp":1790424306309,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","award":["Scholar Award"],"award-info":[{"award-number":["Scholar Award"]}],"id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K99HL150594"],"award-info":[{"award-number":["K99HL150594"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiovascular disease is a leading cause of death in survivors of immune\u2010mediated thrombotic thrombocytopenic purpura (iTTP), but the epidemiology of major adverse cardiovascular events (MACE) in iTTP survivors is unknown. We evaluated the prevalence and risk factors for MACE, defined as the composite of non\u2010fatal or fatal myocardial infarction (MI), stroke, and cardiac revascularization, during clinical remission in two large iTTP cohorts (Johns Hopkins University and Ohio State University). Of 181 patients followed for \u2265 3\u2009months after recovery from acute iTTP, 28.6% had a MACE event over a median follow up of 7.6\u2009years. Stroke was the most common type of MACE (18.2%), followed by non\u2010fatal MI (6.6%), cardiac revascularization (4.9%) and fatal MI (0.6%). Compared to the general United States population, iTTP survivors were younger at first stroke in remission (males [56.5\u2009years vs. 68.6\u2009years, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.031], females [49.7\u2009years vs. 72.9\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt; \u20090.001]) or MI in remission (males [56.5\u2009years vs. 65.6\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt; \u20090.001] and females [53.1\u2009years vs. 72.0\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001]). Age (HR 1.03 [95% CI 1.002\u20131.054]), race (Black\/Other vs. White) (HR 2.32 [95% CI 1.12\u20134.82]), and diabetes mellitus (HR 2.37 [95% CI 1.09\u20130.03]) were associated with MACE in a Cox regression model also adjusted for sex, hypertension, obesity, hyperlipidemia, chronic kidney disease, atrial fibrillation, autoimmune disease, and relapsing iTTP. Remission ADAMTS13 activity was not significantly associated with MACE. In conclusion, iTTP survivors experience high rates of MACE and may benefit from aggressively screening for and managing cardiovascular risk factors.<\/jats:p>","DOI":"10.1002\/ajh.26341","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T14:01:42Z","timestamp":1630332102000},"page":"1587-1594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Major adverse cardiovascular events in survivors of immune\u2010mediated thrombotic thrombocytopenic purpura"],"prefix":"10.1002","volume":"96","author":[{"given":"Max A.","family":"Brodsky","sequence":"first","affiliation":[{"name":"Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthil","family":"Sukumar","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-9873","authenticated-orcid":false,"given":"Sruthi","family":"Selvakumar","sequence":"additional","affiliation":[{"name":"Nova Southeastern University School of Medicine  Fort Lauderdale Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Yanek","sequence":"additional","affiliation":[{"name":"Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hussain","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall A.","family":"Mazepa","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Minnesota School of Medicine  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan M.","family":"Braunstein","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison R.","family":"Moliterno","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Kickler","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Brodsky","sequence":"additional","affiliation":[{"name":"Division 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