{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:27:25Z","timestamp":1791840445127,"version":"4.3.4"},"reference-count":216,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Disease Overview<\/jats:title>\n                    <jats:p>The eosinophilias encompass a broad range of nonhematologic (secondary or reactive) and hematologic (primary or clonal) disorders with potential for end\u2010organ damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis<\/jats:title>\n                    <jats:p>\n                      Hypereosinophilia (HE) has generally been defined as a peripheral blood eosinophil count greater than 1.5\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L. After exclusion of secondary causes of eosinophilia, diagnostic evaluation of primary eosinophilias relies on morphologic review of the blood and marrow, standard cytogenetics, fluorescence in situ hybridization, next generation sequencing gene assays, and flow immunophenotyping to detect histopathologic or clonal evidence for an acute or chronic hematolymphoid neoplasm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Risk Stratification<\/jats:title>\n                    <jats:p>\n                      Disease prognosis relies on identifying the subtype of eosinophilia. After evaluation of secondary causes of eosinophilia, the 2016 World Health Organization endorses a semi\u2010molecular classification scheme of disease subtypes. This includes the major category \u201cmyeloid\/lymphoid neoplasms with eosinophilia and rearrangement of\n                      <jats:italic>PDGFRA<\/jats:italic>\n                      ,\n                      <jats:italic>PDGFRB<\/jats:italic>\n                      , or\n                      <jats:italic>FGFR1<\/jats:italic>\n                      or with\n                      <jats:italic>PCM1\u2010JAK2<\/jats:italic>\n                      \u201d, and the myeloproliferative neoplasm subtype, \u201cchronic eosinophilic leukemia, not otherwise specified\u201d (CEL, NOS). Lymphocyte\u2010variant HE is an aberrant T\u2010cell clone\u2010driven reactive eosinophila, and idiopathic hypereosinophilic syndrome (HES) is a diagnosis of exclusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Risk\u2010adapted Therapy<\/jats:title>\n                    <jats:p>\n                      The goal of therapy is to mitigate eosinophil\u2010mediated organ damage. For patients with milder forms of eosinophilia (eg, &lt; 1.5\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L) without symptoms or signs of organ involvement, a watch and wait approach with close follow\u2010up may be undertaken. Identification of rearranged\n                      <jats:italic>PDGFRA<\/jats:italic>\n                      or\n                      <jats:italic>PDGFRB<\/jats:italic>\n                      is critical because of the exquisite responsiveness of these diseases to imatinib. Corticosteroids are first\u2010line therapy for patients with lymphocyte\u2010variant HE and HES. Hydroxyurea and interferon\u2010\u03b1 have demonstrated efficacy as initial treatment and in steroid\u2010refractory cases of HES. Mepolizumab, an interleukin\u20105 (IL\u20105) antagonist monoclonal antibody, was recently approved by the US Food and Drug Administration for patients with idiopathic HES. The use of the IL\u20105 receptor antibody benralizumab, as well as other targeted therapies such as JAK2 and FGFR1 inhibitors, is under active investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajh.26352","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T10:47:14Z","timestamp":1631875634000},"page":"129-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":173,"title":["World Health Organization\u2010defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-350X","authenticated-orcid":false,"given":"William","family":"Shomali","sequence":"first","affiliation":[{"name":"Division of Hematology, Stanford Cancer Institute Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Gotlib","sequence":"additional","affiliation":[{"name":"Division of Hematology, Stanford Cancer Institute Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25906"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-1-78"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.022"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.287"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-050054"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0787"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2005.11.011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25945"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25811"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80352-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200301000-00017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000193467.06938.77"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025217"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11420"},{"key":"e_1_2_9_16_1","first-page":"963","article-title":"Eosinophilia detected by automated blood cell counting in ambulatory north American outpatients. Incidence and clinical significance","volume":"121","author":"Brigden M","year":"1997","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805283382206"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06038.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.019"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_9_21_1","first-page":"68","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Bain BJ","year":"2008"},{"key":"e_1_2_9_22_1","first-page":"51","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Bain BJ","year":"2008"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286757"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197501000-00001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.02.042"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.10.2759.2759"},{"key":"e_1_2_9_27_1","first-page":"1","article-title":"Clinical features of fifteen patients with the hypereosinophilic syndrome","volume":"52","author":"Spry CJ","year":"1983","journal-title":"Q J Med"},{"key":"e_1_2_9_28_1","first-page":"253","article-title":"Prognostic factors of hypereosinophilic syndrome. Study of 40 cases","volume":"140","author":"Lefebvre C","year":"1989","journal-title":"Ann Med Interne"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V58.5.1012.1012"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.546218"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-1824"},{"key":"e_1_2_9_32_1","first-page":"1233","article-title":"Hypereosinophilic syndrome with extensive myocardial involvement and mitral valve thrombus instead of mural thrombi","volume":"33","author":"Tanino M","year":"1983","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951102000136"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00841-9"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03637.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132009000600010"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-9011-2"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-695973"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089169107700616"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01697986"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb07174.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13957"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23193"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13889"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct051"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1627"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16340"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0006"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2598-x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404662"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3067-x"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-110388"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.240"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa208"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2004.01.013"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-84"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.5.1735"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.10.5712"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.4.637"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16294"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001282"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.20.00366"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001708"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2017.05.001"},{"issue":"2","key":"e_1_2_9_65_1","first-page":"614","article-title":"Myeloid\/lymphoid neoplasms with eosinophilia\/basophilia and ETV6\u2010ABL1 fusion: cell\u2010of\u2010origin and response to tyrosine kinase inhibition","volume":"106","author":"Yao J","year":"2021","journal-title":"Haematologica"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00817-7"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1397663"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.187302"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.165340"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17026"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04195.x"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910073411503"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00465.x"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24075"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.75"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0342-3"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001385"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004237"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199402243300804"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.1071"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.4.1416.bloodjournal8741416"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01765"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000088"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.3.994.415k26_994_1002"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097684"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-472720"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-654277"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001604"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.010421"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.005447"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182a71eba"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.127003"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.12.016"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.73"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400839"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02097.x"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199709059688"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0632-4"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25036"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0947"},{"key":"e_1_2_9_101_1","volume-title":"Hematology","author":"Ackerman SJ","year":"2005"},{"key":"e_1_2_9_102_1","first-page":"9","article-title":"Case report: rapid and complete control of idiopathic hypereosinophilia with imatinib mesylate","volume":"3","author":"Schaller JL","year":"2001","journal-title":"MedGenMed"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08505-7"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00046-2"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0932698100"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2798"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07033.x"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.162"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-100164"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001111"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23588"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403600"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06221.x"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.2"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-004580"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00108-9"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-004457"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1932"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-0285"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.181"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0487"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.11.027"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.70"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-024828"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-555607"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.129"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-817510"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3103"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2393"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404438101"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.066407"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.188"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.136"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.2812.2812"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy173"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002308"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-433821"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.4370"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2451-7"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25825"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020004174"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-343426"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.168"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.144345"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.731602"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-2-167"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.8.2284.bloodjournal8582284"},{"key":"e_1_2_9_148_1","first-page":"651","article-title":"\u03b1IFN\u2013induced hematologic and cytogenetic remission in chronic eosinophilic leukemia with t(1;5)","volume":"84","author":"Luciano L","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199806)58:2<137::AID-AJH9>3.0.CO;2-T"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.00298.x"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90348-4"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050434"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2000.tb02131.x"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085560"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23018"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-143537"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.6075"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1159\/000206350"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199211000-00012"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2002.43.2.267"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910601)67:11<2826::AID-CNCR2820671119>3.0.CO;2-#"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-11-199412010-00022"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400717"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21186"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01729838"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.4.630"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-835330"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.12.001"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-9831-1"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16332"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.055"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31322-8"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.049"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031261"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.049"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3620"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.116576"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070812"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.08.037"},{"key":"e_1_2_9_180_1","first-page":"329","article-title":"Reslizumab, a humanized anti\u2010IL\u20105 mAb for the treatment of eosinophil\u2010mediated inflammatory conditions","volume":"11","author":"Walsh GM","year":"2009","journal-title":"Curr Opin Mol Ther"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.02.017"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.11.044"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31324-1"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703501"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812185"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.04.033"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05206.x"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04801.x"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1302"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.09.018"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702102"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701783"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199809059261"},{"key":"e_1_2_9_194_1","first-page":"647","article-title":"Hypereosinophilic syndrome: successful allogeneic bone marrow transplantation","volume":"15","author":"Sigmund DA","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199602)51:2<164::AID-AJH12>3.0.CO;2-I"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700729"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703379"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03771.x"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705437"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-4-650_2"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-96-6-791_1"},{"key":"e_1_2_9_202_1","first-page":"83","article-title":"Management of hypereosinophilic syndrome with chronic plasma\u2010 and leukapheresis","volume":"337","author":"Chambers LA","year":"1990","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05309.x"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-1-109"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107689809100912"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90929-9"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)64701-7"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1985.tb123104.x"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2008.00639.x"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(96)00947-2"},{"key":"e_1_2_9_211_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1320"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11841"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271256"},{"key":"e_1_2_9_214_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.65.5.700"},{"key":"e_1_2_9_215_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034912"},{"key":"e_1_2_9_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.950"},{"key":"e_1_2_9_217_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012047"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.26352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T22:32:05Z","timestamp":1693089125000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.26352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,8]]},"references-count":216,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/ajh.26352"],"URL":"https:\/\/doi.org\/10.1002\/ajh.26352","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,8]]},"assertion":[{"value":"2021-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}