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Most patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0387, 97.4%) received mRNA\u2010based vaccines. Most of the recipients (93%) were vaccinated more than 1\u00a0year after transplant. Detectable SARS\u2010CoV\u20102\u2010reactive antibodies were observed in 242 (78%) of allo\u2010HSCT and in 73 (85%) of ASCT recipients. Multivariate analysis in allo\u2010HSCT recipients identified lymphopenia &lt; 1\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/ml (odds ratio [OR] 0.33, 95% confidence interval [95% CI] 0.16\u20130.69, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003), active graft versus host disease (GvHD; OR 0.51, 95% CI 0.27\u20130.98, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04) and vaccination within the first year of transplant (OR 0.3, 95% CI 0.15\u20130.9, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04) associated with lower antibody detection whereas. In ASCT, non\u2010Hodgkin's lymphoma (NHL; OR 0.09, 95% CI 0.02\u20130.44, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003) and active corticosteroid therapy (OR 0.2, 95% CI 0.02\u20130.87, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03) were associated with lower detection rate. We report an encouraging rate of SARS\u2010CoV\u20102\u2010reactive antibodies detection in these severe immunocompromised patients. Lymphopenia, GvHD, the timing of vaccine, and NHL and corticosteroids therapy should be considered in allo\u2010HSCT and ASCT, respectively, to identify candidates for SARS\u2010CoV\u20102 antibodies monitoring.<\/jats:p>","DOI":"10.1002\/ajh.26385","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T17:49:08Z","timestamp":1635184148000},"page":"30-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["<scp>SARS\u2010CoV<\/scp>\u20102\u2010reactive antibody detection after <scp>SARS\u2010CoV<\/scp>\u20102 vaccination in hematopoietic stem cell transplant recipients: Prospective survey from the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-2562","authenticated-orcid":false,"given":"Jos\u00e9 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