{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T16:15:22Z","timestamp":1784391322790,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K08345"],"award-info":[{"award-number":["18K08345"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We compared characteristics of myeloid neoplasms (MNs) following allogeneic hematopoietic cell transplantation (HCT) versus autologous HCT using a Japanese HCT registry database. Among 43\u2009788 patients who underwent allogeneic (<jats:italic>n<\/jats:italic>\u00a0=\u00a018\u2009874) or autologous HCT (<jats:italic>n<\/jats:italic>\u00a0=\u00a024\u2009914) for non\u2010myeloid malignancies or non\u2010malignant diseases, 352 developed MNs. The cumulative incidence of MNs was lower after allogeneic HCT than after autologous HCT (0.3% vs. 1.8% at 10\u2009years, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Compared with autologous HCT, MNs following allogeneic HCT developed in younger patients (median, 42 vs. 57\u2009years old, respectively) and sooner after HCT (median, 16 vs. 33\u2009months, respectively). Approximately half of MNs following allogeneic HCT were donor\u2010derived and occurred later than recipient\u2010derived MNs (median, 26 vs. 6\u00a0months, respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003). In multivariate analysis, reduced\u2010intensity conditioning and cord blood transplantation were associated with MN development after allogeneic HCT. Overall survival was similar in patients who developed MNs following allogeneic versus autologous HCT (18% vs. 22% at 5\u2009years, respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.48). Patient age \u2265 55\u2009years, the presence of previous HCT, AML subtype, and chromosome 5 or 7 abnormalities were adverse factors for overall survival after MN diagnosis. Further research is warranted to elucidate the mechanisms of MN development following allogeneic HCT.<\/jats:p>","DOI":"10.1002\/ajh.26401","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T07:53:53Z","timestamp":1636098833000},"page":"185-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of myeloid neoplasms following allogeneic hematopoietic cell transplantation"],"prefix":"10.1002","volume":"97","author":[{"given":"Masatomo","family":"Kuno","sequence":"first","affiliation":[{"name":"Department of Hematology, Graduate School of Medicine Osaka City University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyushu University Beppu Hospital  Beppu 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