{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:21:28Z","timestamp":1778646088519,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>FMS\u2010like tyrosine kinase 3 internal tandem duplication (<jats:italic>FLT3\u2010ITD<\/jats:italic>) mutational status is a pivotal prognosticator in acute myeloid leukemia (AML) patients and significantly increases the risk of disease relapse. However, it remains unclear whether in <jats:italic>FLT3\u2010ITD<\/jats:italic> patients referred for allogeneic stem cell transplantation (allo\u2010SCT), baseline cytogenetics significantly impacts clinical outcome. Using the European Society of Blood and Marrow Transplantation registry, we performed a retrospective analysis of 1631 <jats:italic>FLT3\u2010ITD<\/jats:italic> AML patients who underwent allo\u2010SCT with the aim of determining the influence of cytogenetic risk category on patient outcomes. Median patient age was 49\u2009years and median follow\u2010up duration was 36\u2009months. Two\u2010year leukemia\u2010free survival (LFS) and incidence of relapse were 54% and 31.6%, respectively. Non\u2010relapse mortality was experienced by 14.4% with a 2\u2010year overall survival (OS) of 60.1%. On multivariate analysis, LFS was significantly lower in patients with intermediate and adverse risk cytogenetics compared with those with favorable risk cytogenetics, (hazard ratio [HR]\u00a0=\u00a01.48, 95% confidence interval [CI], 1.06\u20132.06; <jats:italic>p<\/jats:italic>\u00a0=\u2009.02), and (HR\u00a0=\u00a001.65, 95% CI, 1.13\u20132.40; <jats:italic>p<\/jats:italic>\u00a0=\u2009.009), respectively. OS was significantly lower in patients with adverse risk cytogenetics compared with patients with favorable risk cytogenetics (HR\u00a0=\u00a01.74, 95% CI, 1.16\u20132.61; <jats:italic>p<\/jats:italic>\u00a0=\u2009.008) with a trend toward lower OS in patients with intermediate risk cytogenetics compared to those with favorable risk cytogenetics (HR\u00a0=\u00a01.43, 95% CI, 1.00\u20132.05; <jats:italic>p<\/jats:italic>\u00a0=\u2009.052). In addition, adverse risk patients and intermediate risk patients experienced higher relapse rates compared with favorable risk patients (HR\u00a0=\u00a01.83, 95% CI, 1.13\u20132.94; <jats:italic>p<\/jats:italic>\u00a0=\u2009.013 and HR\u00a0=\u00a01.82, 95% CI, 1.19\u20132.77; <jats:italic>p<\/jats:italic>\u00a0=\u2009.005). Overall, cytogenetic studies aid in refinement of risk stratification in transplanted <jats:italic>FLT3\u2010ITD<\/jats:italic> AML patients.<\/jats:p>","DOI":"10.1002\/ajh.26442","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T17:42:37Z","timestamp":1641231757000},"page":"274-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cytogenetic risk classification maintains its prognostic significance in transplanted <i>FLT3\u2010ITD<\/i> mutated acute myeloid leukemia patients: On behalf of the <scp>acute leukemia working party<\/scp>\/<scp>European society of blood and marrow transplantation<\/scp>"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-1265","authenticated-orcid":false,"given":"Arnon","family":"Nagler","sequence":"first","affiliation":[{"name":"Hematology Division, Department of Bone Marrow Transplantation, Sheba Medical Center, Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint\u2010Antoine, EBMT ALWP Office  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Craddock","sequence":"additional","affiliation":[{"name":"Centre for Clinical Haematology Queen Elizabeth Hospital  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, Hematology Stem Cell Transplantation Saint Louis Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Yakoub\u2010Agha","sequence":"additional","affiliation":[{"name":"CHU de Lille, University of Lille, INSERM, U1285  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Gedde\u2010Dahl","sequence":"additional","affiliation":[{"name":"Hematology Department, Section for Stem Cell Transplantation Oslo University Hospital, Rikshospitalet, Clinic for Cancer Medicine  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riitta","family":"Niittyvuopio","sequence":"additional","affiliation":[{"name":"HUCH Comprehensive Cancer Center  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Louise","family":"Byrne","sequence":"additional","affiliation":[{"name":"Nottingham University  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan J.","family":"Cornelissen","sequence":"additional","affiliation":[{"name":"Erasmus MC\u2010Daniel den Hoed Cancer Centre  Rotterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Labussi\u00e8re\u2010Wallet","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Lyon Sud, Pavillon Marcel B\u00e9rard, Service Hematologie  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Arcese","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Unit, Policlinico Universitario Tor Vergata University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Milpied","sequence":"additional","affiliation":[{"name":"Hematology and Cell Therapy Department Bordeaux University Hospital  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Esteve","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Cl\u00ednic of Barcelona, IDIBAPS University of Barcelona  Barcelona 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