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We investigated the efficacy, safety, prognostic factors, and optimal therapeutic protocol for SR\u2010aGVHD patients treated with basiliximab in a real\u2010world setting. Nine hundred and forty SR\u2010aGVHD patients were recruited from 36 hospitals in China, and 3683 doses of basiliximab were administered. Basiliximab was used as monotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a0642) or in combination with other second\u2010line treatments (<jats:italic>n<\/jats:italic>\u00a0=\u00a0298). The cumulative incidence of overall response rate (ORR) at day 28 after basiliximab treatment was 79.4% (95% confidence interval [CI] 76.5%\u201382.3%). The probabilities of nonrelapse mortality and overall survival at 3\u2009years after basiliximab treatment were 26.8% (95% CI 24.0%\u201329.6%) and 64.3% (95% CI 61.2%\u201367.4%), respectively. A 1:1 propensity score matching was performed to compare the efficacy and safety between the monotherapy and combined therapy groups. Combined therapy did not increase the ORR; conversely, it increased the infection rates compared with monotherapy. The multivariate analysis showed that combined therapy, grade III\u2013IV aGVHD, and high\u2010risk refined Minnesota aGVHD risk score before basiliximab treatment were independently associated with the therapeutic response. Hence, we created a prognostic scoring system that could predict the risk of having a decreased likelihood of response after basiliximab treatment. Machine learning was used to develop a protocol that maximized the efficacy of basiliximab while maintaining acceptable levels of infection risk. Thus, real\u2010world data suggest that basiliximab is safe and effective for treating SR\u2010aGVHD.<\/jats:p>","DOI":"10.1002\/ajh.26475","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T14:59:42Z","timestamp":1642863582000},"page":"458-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Basiliximab for steroid\u2010refractory acute graft\u2010versus\u2010host disease: A real\u2010world analysis"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9881-7945","authenticated-orcid":false,"given":"Xiao\u2010Dong","family":"Mo","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"},{"name":"Research Unit of Key Technique for Diagnosis and 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