{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:36:33Z","timestamp":1780360593155,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009812","name":"Princess Margaret Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pretransplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed\/refractory classical Hodgkin lymphoma (cHL). However, the prognostic value of residual metabolic tumor volume (rMTV) in patients with DS 4\u20135 has been less well characterized. We retrospectively assessed 106 patients with relapsed\/refractory cHL who underwent autologous stem cell transplantation. Pretransplant DS was determined as 1\u20133 (59%) and 4\u20135 (41%), with a markedly inferior event\u2010free survival (EFS) in patients with DS 4\u20135 (hazard ratio [HR], 3.14; <jats:italic>p<\/jats:italic>\u00a0=\u2009.002). High rMTV<jats:sub>41%<\/jats:sub> (rMTV<jats:sub>high<\/jats:sub>, \u22654.4\u00a0cm<jats:sup>3<\/jats:sup>) predicted significantly poorer EFS in patients with DS 4\u20135 (HR, 3.70; <jats:italic>p<\/jats:italic>\u00a0=\u2009.014). In a multivariable analysis, we identified two independent factors predicting treatment failure: pretransplant DS combined with rMTV<jats:sub>41%<\/jats:sub> and disease status (primary refractory <jats:italic>vs<\/jats:italic>. relapsed). These two factors allow to stratify patients into three groups with divergent 2\u2010year EFS: 89% for low\u2010risk (51%; relapsed disease and either pretransplant DS 1\u20133 or DS 4\u20135\/rMTV<jats:sub>low<\/jats:sub>; HR 1), 65% for intermediate\u2010risk (28%; refractory disease and either DS 1\u20133 or DS 4\u20135\/rMTV<jats:sub>low<\/jats:sub>; HR 3.26), and 45% for high\u2010risk (21%; DS 4\u20135\/rMTV<jats:sub>high<\/jats:sub> irrespective of disease status; HR 7.61) groups. Pretransplant DS\/rMTV<jats:sub>41%<\/jats:sub> combination and disease status predict the risk of post\u2010transplant treatment failure and will guide risk\u2010stratified approaches in relapsed\/refractory cHL.<\/jats:p>","DOI":"10.1002\/ajh.26500","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T13:16:13Z","timestamp":1645017373000},"page":"583-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk stratification for relapsed\/refractory classical Hodgkin lymphoma integrating pretransplant Deauville score and residual metabolic tumor volume"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-5336","authenticated-orcid":false,"given":"Ho\u2010Young","family":"Yhim","sequence":"first","affiliation":[{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre \u2013 University Health Network  Toronto Ontario 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Margaret Cancer Centre, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Rodin","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program Princess Margaret Cancer Centre \u2013 University Health Network  Toronto Ontario Canada"},{"name":"Department of Radiation Oncology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program Princess Margaret Cancer Centre \u2013 University Health Network  Toronto Ontario Canada"},{"name":"Department of Radiation Oncology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Tsang","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program Princess Margaret Cancer Centre \u2013 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