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However, the efficacy reportedly ranges from 50% to 90%, and factors affecting anti\u2010CMV efficacy have not been established. We investigated the safety and efficacy of adoptive therapy with CMV\u2010CTLs for CMV infection in 190 patients after haploidentical stem cell transplantation (haplo\u2010SCT), and importantly, we analyzed the main factors affecting antiviral efficacy. The CMV peak titer decreased from 19 (range, 1.0\u2013503.0)\u2009\u00d7\u200910<jats:sup>3<\/jats:sup>\u2009copies\/mL to 3.9 (range, 0\u2013112)\u2009\u00d7\u200910<jats:sup>3<\/jats:sup>\u2009copies\/mL after CMV\u2010CTL infusion. The cumulative complete response (CR) rates in the first, fourth, and sixth weeks after the first CMV\u2010CTL infusion were 37.9% (95% CI 35.0\u201340.8), 76.8% (95% CI 70.7\u201382.9), and 89.5% (95% CI 85.2\u201393.8), respectively. In multivariate analysis, persistent CMV infection prior to CMV\u2010CTL infusion (hazard ratio [HR] 2.29, 95% CI 1.29\u20134.06, <jats:italic>p<\/jats:italic>\u00a0=\u2009.005) and basiliximab treatment within 2\u2009weeks of CMV\u2010CTL infusion (HR 1.87, 95% CI 1.06\u20133.81, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.031) were independent predictors of poor antiviral efficacy of CMV\u2010CTL therapy. Our data showed that adoptive therapy with CMV\u2010CTLs is a safe and effective treatment for CMV infection after haplo\u2010SCT. Persistent CMV infection and basiliximab treatment are correlated with poor anti\u2010CMV efficacy of CMV\u2010CTL therapy.<\/jats:p>","DOI":"10.1002\/ajh.26535","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T08:09:58Z","timestamp":1647418198000},"page":"762-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Adoptive therapy with <scp>cytomegalovirus<\/scp>\u2010specific T cells for <scp>cytomegalovirus<\/scp> infection after haploidentical stem cell transplantation and factors affecting efficacy"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1200-7763","authenticated-orcid":false,"given":"Xu\u2010Ying","family":"Pei","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8139-1773","authenticated-orcid":false,"given":"Xiang\u2010Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"},{"name":"Peking\u2010Tsinghua Center for Life Sciences  Beijing 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Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1253-7465","authenticated-orcid":false,"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-6050","authenticated-orcid":false,"given":"Ying\u2010Jun","family":"Chang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic 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