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Here, we present patient\u2010reported outcomes (PROs) from the ANDROMEDA trial. PROs were assessed through cycle 6 using three standardized questionnaires. Treatment effect through cycle 6 was measured by a repeated\u2010measures, mixed\u2010effects model. The magnitude of changes in PROs versus baseline was generally low, but between\u2010group differences favored the D\u2010VCd group. Results were generally consistent irrespective of hematologic, cardiac, or renal responses. More patients in the D\u2010VCd group experienced meaningful improvements in PROs; median time to improvement was more rapid in the D\u2010VCd group versus the VCd group. After cycle 6, patients in the D\u2010VCd group received daratumumab monotherapy and their PRO assessments continued, with improvements in health\u2010related quality of life (HRQoL) reported through cycle 19. PROs of subgroups with renal and cardiac involvement were consistent with those of the intent\u2010to\u2010treat population. These results demonstrate that the previously reported clinical benefits of D\u2010VCd were achieved without decrement to patients' HRQoL and provide support of D\u2010VCd in patients with AL amyloidosis.<\/jats:p>","DOI":"10.1002\/ajh.26536","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T08:10:35Z","timestamp":1647418235000},"page":"719-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Health\u2010related quality of life in patients with <scp>light chain<\/scp> amyloidosis treated with bortezomib, cyclophosphamide, and dexamethasone\u2009\u00b1\u2009daratumumab: Results from the <scp>ANDROMEDA<\/scp> study"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-2445","authenticated-orcid":false,"given":"Vaishali","family":"Sanchorawala","sequence":"first","affiliation":[{"name":"Amyloidosis Center, Department of Hematology Boston 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