{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:35:16Z","timestamp":1788878116975,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Monoclonal gammopathy of renal significance (MGRS) is a recognized clinical entity. Literature regarding treatment and its outcomes in MGRS is sparse due to the rarity and misdiagnosis of MGRS. We retrospectively analyzed 280 adults with an MGRS diagnosis from 2003 to 2020 across 19 clinical centers from 12 countries. All cases required renal biopsy for the pathological diagnosis of MGRS. Amyloidosis\u2010related to MGRS (MGRS\u2010A) was present in 180 patients; nonamyloidosis MGRS (MGRS\u2010NA), including a broad spectrum of renal pathologies, was diagnosed in 100 patients. The median overall survival in the studied cohort was 121.0\u00a0months (95% CI: 105.0\u2013121.0). Patients with MGRS\u2010A had a shorter overall survival than patients with MGRS\u2010NA (HR\u00a0=\u00a00.41, 95%CI: 0.25\u20130.69;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0007). Both hematologic and renal responses were associated with longer survival. Achievement of \u2265VGPR was generally predictive of a renal response (OR\u00a0=\u00a08.03 95%CI: 4.04\u2013115.96;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), one\u2010fourth of patients with \u2265VGPR were renal nonresponders. In MGRS\u2010A, factors associated with poor prognosis included elevated levels of creatinine, beta\u20102\u2010microglobulin, and hemodialysis at diagnosis. In MGRS\u2010NA, only age &gt;65\u2009years was associated with increased risk of death. Treatments provided similar hematologic response rates in both types of MGRS. Autologous stem cell transplantation led to better response than other treatments. This multicenter and international effort is currently the largest report on MGRS.\n                  <\/jats:p>","DOI":"10.1002\/ajh.26566","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T10:36:25Z","timestamp":1649327785000},"page":"877-884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Monoclonal gammopathy of renal significance (MGRS): Real\u2010world data on outcomes and prognostic factors"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0769-6891","authenticated-orcid":false,"given":"Alessandro","family":"Gozzetti","sequence":"first","affiliation":[{"name":"Hematology, Department of Medical Science, Surgery and Neuroscience University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Guarnieri","sequence":"additional","affiliation":[{"name":"Nephrology Azienda Ospedaliera Universitaria Senese  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zamagni","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d  Bologna Italy"},{"name":"Dipartimento di Medicina Specialistica Diagnostica e Sperimentale Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zakharova","sequence":"additional","affiliation":[{"name":"Department of Nephrology Moscow City Hospital named after S.P. Botkin  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Coriu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fundeni Clinical Institute University of Medicine and Pharmacy \"Carol Davila\"  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Bittrich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Pika","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology University Hospital Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Tovar","sequence":"additional","affiliation":[{"name":"Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Cl\u00ednic of Barcelona Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Schutz","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital del Salvador  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ciofini","sequence":"additional","affiliation":[{"name":"Hematology, Department of Medical Science, Surgery and Neuroscience University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital del Salvador  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Rocchi","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d  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