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After HDS269B infusion (9\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> CAR<jats:sup>+<\/jats:sup> cells\/kg), 17 patients (34.69%, 11 ECOG 0\u20132, 6 ECOG 3\u20134) developed cytokine release syndrome [grade 1\u20132: 14 patients (28.57%); grade 3: 3 patients (6.12%)]. The objective response rate (ORR) was 77%, with a complete response (CR) achieved in 47%. Ongoing response &gt;12\u2009months occurred in 15 patients, and was extended beyond 38\u2009months in one patient. The median progression\u2010free survival (PFS) and overall survival (OS) were 10\u00a0months (95% CI 5.3\u201314.7) and 29\u2009months (95% CI 10.0\u201348.0), respectively. The PFS (12\u2009months) and OS (18\u2009months) rates were 41.64% and 62.76%, respectively. In patients with ECOG 0\u20132 and 3\u20134, ORR was 79.31% (23\/29) and 75.0% (15\/20) and PFS were 15\u2009months (95% CI 5.4\u201324.6) and 4\u00a0months (95% CI 0\u201311.7), respectively. OS was not reached in ECOG 0\u20132 patients, but was 10.5\u00a0months (95% CI 0\u201322) in ECOG 3\u20134 patients. Single\u2010cell sequencing indicated that treatment efficacy might be related to mTORC1 signaling. Thus, HDS269B therapy is safe and effective for RRMM patients, even those with ECOG 3\u20134.<\/jats:p>","DOI":"10.1002\/ajh.26583","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T05:07:08Z","timestamp":1651295228000},"page":"933-941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["<scp>CAR\u2010T<\/scp> cell therapy targeting B cell maturation antigen is effective for relapsed\/refractory multiple myeloma, including cases with poor performance status"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2538-4007","authenticated-orcid":false,"given":"Juan","family":"Du","sequence":"first","affiliation":[{"name":"Department of Hematology Myeloma &amp; Lymphoma Center, Changzheng Hospital, Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runhong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hematology Henan Province Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine), Institute of Hematology, Henan University of Traditional Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songfu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Wenzhou Medical University, Wenzhou  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology Myeloma &amp; Lymphoma Center, Changzheng Hospital, Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Myeloma &amp; Lymphoma Center, Changzheng Hospital, Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Qiang","sequence":"additional","affiliation":[{"name":"Department of Hematology Myeloma &amp; Lymphoma Center, Changzheng Hospital, Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology Myeloma &amp; Lymphoma Center, Changzheng Hospital, Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Hematology Henan Province Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine), Institute of Hematology, Henan University of Traditional Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hematology Henan Province Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine), Institute of Hematology, Henan University of Traditional Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Wenzhou Medical University, Wenzhou  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Wenzhou Medical University, Wenzhou  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyi","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Wenzhou Medical University, Wenzhou  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedong","family":"Sun","sequence":"additional","affiliation":[{"name":"HRAIN Biotechnology Co., Ltd.  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