{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:22:36Z","timestamp":1792686156125,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Therapy\u2010related myeloid neoplasms (t\u2010MN) are aggressive malignancies in need of effective therapies. The BCL\u20102 inhibitor venetoclax represents a paradigm shift in the treatment of acute myeloid leukemia. However, the effectiveness of venetoclax has not been studied in a large cohort of t\u2010MN. We retrospectively analyzed 378\u2009t\u2010MN patients, of which 96 (25.4%, 47 therapy\u2010related acute myeloid leukemia, 1 therapy\u2010related chronic myelomonocytic leukemia, 48 therapy\u2010related myelodysplastic syndrome) received venetoclax. Median interval from t\u2010MN to venetoclax initiation was 2.9 (Interquartile range [IQR] 0.7\u201312) months, and patients received a median of 3 (IQR 1\u20134) cycles. The composite complete remission (CRc) rate, median progression\u2010free survival (PFS), and overall survival (OS) were 39.1%, 4.9\u00a0months, and 7\u00a0months, respectively. The upfront use of venetoclax and achieving CRc were associated with improved survival, whereas the presence of Chromosome 7 abnormalities was associated with an inferior survival. Neither the TP53\u2010status nor the percent bone marrow blast predicted the likelihood of CRc or survival. Paired genetic analysis performed at venetoclax initiation and failure did not show the evidence of the selection of the <jats:italic>TP53<\/jats:italic>\u2010mutated clone. In a propensity\u2010matched analysis, the use of venetoclax\u2010based regimen as the first\u2010line therapy was associated with a superior survival compared to hypomethylating agent (HMA)\u2010based first\u2010line therapy (9.4 vs. 6.1\u2009months, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). We conclude that the upfront use of venetoclax with HMA improved survival, though PFS and OS remain poor. As the phenotype at diagnosis or the percent blasts did not predict outcomes, venetoclax should be studied in all t\u2010MN phenotypes.<\/jats:p>","DOI":"10.1002\/ajh.26589","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T03:58:06Z","timestamp":1652414286000},"page":"1013-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Outcomes following venetoclax\u2010based treatment in therapy\u2010related myeloid neoplasms"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5359-336X","authenticated-orcid":false,"given":"Mithun Vinod","family":"Shah","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-6547","authenticated-orcid":false,"given":"Rakchha","family":"Chhetri","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Central Adelaide Local Health Network  Adelaide South Australia"},{"name":"University of Adelaide  Adelaide South Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchita","family":"Dholakia","sequence":"additional","affiliation":[{"name":"Robert D. and Patricia E. Kern Center for Science of Health Care Delivery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3181-7852","authenticated-orcid":false,"given":"Chung H.","family":"Kok","sequence":"additional","affiliation":[{"name":"Precision Medicine Theme South Australian Health and Medical Research Institute (SAHMRI)  Adelaide South Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9104-6172","authenticated-orcid":false,"given":"Naseema","family":"Gangat","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-8404","authenticated-orcid":false,"given":"Hassan B.","family":"Alkhateeb","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aref","family":"Al\u2010Kali","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6998-662X","authenticated-orcid":false,"given":"Mrinal M.","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3432-0489","authenticated-orcid":false,"given":"Anmol","family":"Baranwal","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-9011","authenticated-orcid":false,"given":"Patricia T.","family":"Greipp","sequence":"additional","affiliation":[{"name":"Division of Hematopathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6116-8163","authenticated-orcid":false,"given":"Rong","family":"He","sequence":"additional","affiliation":[{"name":"Robert D. and Patricia E. 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