{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:59:42Z","timestamp":1792828782911,"version":"4.5.0"},"reference-count":187,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA 168762"],"award-info":[{"award-number":["CA 168762"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA 186781"],"award-info":[{"award-number":["CA 186781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Disease Overview<\/jats:title>\n                    <jats:p>Multiple myeloma accounts for approximately 10% of hematologic malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis<\/jats:title>\n                    <jats:p>\n                      The diagnosis requires \u226510% clonal bone marrow plasma cells or a biopsy\u2010proven plasmacytoma\n                      <jats:italic>plus<\/jats:italic>\n                      evidence of one or more multiple myeloma defining events (MDE): CRAB (hyper\n                      <jats:italic>c<\/jats:italic>\n                      alcemia,\n                      <jats:italic>r<\/jats:italic>\n                      enal failure,\n                      <jats:italic>a<\/jats:italic>\n                      nemia, or lytic\n                      <jats:italic>b<\/jats:italic>\n                      one lesions) attributable to the plasma cell disorder, bone marrow clonal plasmacytosis \u226560%, serum involved\/uninvolved free light chain (FLC) ratio\u2009\u2265\u2009100 (provided involved FLC is \u2265100\u2009mg\/L), or &gt;1 focal lesion on magnetic resonance imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Risk Stratification<\/jats:title>\n                    <jats:p>The presence of del(17p), t(4;14), t(14;16), t(14;20), gain 1q, or p53 mutation is considered high\u2010risk multiple myeloma. The presence of any two high risk factors is considered double\u2010hit myeloma, and three or more high risk factors is triple\u2010hit myeloma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Risk\u2010Adapted Initial Therapy<\/jats:title>\n                    <jats:p>In patients who are candidates for autologous stem cell transplantation, induction therapy consists of bortezomib, lenalidomide, dexamethasone (VRd) given for approximately 3\u20134\u00a0cycles followed by autologous stem cell transplantation (ASCT). In high\u2010risk patients, daratumumab, bortezomib, lenalidomide, dexamethasone (Dara\u2010VRd) is an alternative to VRd. Selected standard\u2010risk patients can collect stem cells, get additional cycles of induction therapy, and delay transplant until first relapse. Patients who are not candidates for transplant are treated with VRd for approximately 8\u201312\u2009cycles followed by maintenance or alternatively with daratumumab, lenalidomide, dexamethasone (DRd) until progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Maintenance Therapy<\/jats:title>\n                    <jats:p>Standard\u2010risk patients need lenalidomide maintenance, while bortezomib plus lenalidomide maintenance is needed for high\u2010risk myeloma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management of Relapsed Disease<\/jats:title>\n                    <jats:p>A triplet regimen is usually needed at relapse, with the choice of regimen varying with each successive relapse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajh.26590","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T23:59:06Z","timestamp":1652399946000},"page":"1086-1107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":776,"title":["Multiple myeloma: 2022 update on diagnosis, risk stratification, and management"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5862-1833","authenticated-orcid":false,"given":"S. Vincent","family":"Rajkumar","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-00359-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20652"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.134"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4065\/78.1.21"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.336"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30309-2"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.29"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-194241"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-195008"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054494"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60482-5"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-019-0263-z"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.34"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.97"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa01133202"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709974"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.06.014"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070389"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.86"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.4923"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0030-3"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.4065\/81.12.1575"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12478"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0603"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.160"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20794"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2006.04.014"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.78"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00587-0"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.307"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30206-6"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0018-y"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30954-0"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc746"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204641"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1417.h81602001417_1417_1424"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01195-1"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.92"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.94"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31594-X"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611750"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.211"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-134538"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00466-6"},{"key":"e_1_2_12_48_1","first-page":"3138","article-title":"Overall survival of transplant eligible patients with newly diagnosed multiple myeloma: comparative effectiveness analysis of modern induction regimens on outcome","volume":"130","author":"Paquin A","year":"2017","journal-title":"Blood"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70143-7"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.91"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.242"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.61"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-390658"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.313"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911183412102"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043445"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2817"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201004\u2010015909"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61424-9"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.26"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-395749"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-268862"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563759"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411321"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-643320"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607751"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606038"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-785246"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30734-0"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516282"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805762"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32556-5"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00592-4"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177319"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244851"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244917"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/8466"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.11.030"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-167767"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.123"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505654"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506348"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)01120\u20104"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-740787"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30788-0"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817249"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31240-1"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008787"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30452-6"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300439"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.8001"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.4065\/83.10.1142"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-297853"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70284-0"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404801"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.6844"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-344333"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2405062"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-693580"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70187-X"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.8216"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70081-X"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.82"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-422683"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.538.538"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-123465"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06639.x"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-264333"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0198-0"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.536.536"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32956-3"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607113350204"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022340"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0073"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01077-5"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.9.3131"},{"issue":"1","key":"e_1_2_12_119_1","first-page":"685a","article-title":"Front\u2010line or rescue autologous bone marrow transplantation (ABMT) following a first course of high dose melphalan (HDM) in multiple myeloma (MM). Preliminary results of a prospective randomized trial (CIAM) protocol","volume":"88","author":"Facon T","year":"1996","journal-title":"Blood"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.5807"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032290"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.2509"},{"issue":"1","key":"e_1_2_12_123_1","first-page":"S59","article-title":"Single versus tandem high dose therapy (HDT) supported with autologous blood stem cell (ABSC) transplantation using unselected or CD34\u2010enriched ABSC: results of a two by two designed randomized trial in 230 young patients with multiple myeloma (MM)","volume":"4","author":"Fermand JP","year":"2003","journal-title":"Hematol J"},{"issue":"1","key":"e_1_2_12_124_1","first-page":"S61","article-title":"Single vs. tandem autolgous transplantation in multiple myeloma: the GMMG experience","volume":"4","author":"Goldschmidt H","year":"2003","journal-title":"Hematol J"},{"key":"e_1_2_12_125_1","first-page":"401","article-title":"Double autologous stem cell transplantation significantly prolongs progression\u2010free survival and overall survival in comparison with single autotransplantation in newly diagnosed multiple myeloma: an analysis of phase 3 EMN02\/HO95 study","volume":"130","author":"Cavo M","year":"2017","journal-title":"Blood"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00685"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70243-1"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065464"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-173526"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114138"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114083"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402888"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.6820"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112704"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402551"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.34.15_suppl.8001"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30687-9"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.335"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)33003-4"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00428-9"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.4065\/79.7.867"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.196"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30756-7"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.5032"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14787"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00128-5"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.99"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.2679"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1609835"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30070-3"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00464-7"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30578-8"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.208272"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.6802"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.190"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-348896"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-538835"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70380-2"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0024-1"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71125-8"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903455"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32292-3"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.5460"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-788786"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31711-8"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817226"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024850"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00933-8"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14481"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.110890"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00223"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26379"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01338-6"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003805"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0620-8"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-141219"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19425"},{"key":"e_1_2_12_178_1","unstructured":"NeaR.An international randomized double blind trial comparing Denosumab with Zoledronic acid (ZA) for the treatment of bone disease in patients (pts) with newly diagnosed multiple myeloma. 16th International Myeloma Workshop (IMW); March 1\u20134 2017; New Delhi India Abstracts 546 2017 e28."},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00283-0"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.5942"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-568899"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0077-4"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-00366-3"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1993.tb00148.x"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.212"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30124-3"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00335-5"},{"key":"e_1_2_12_188_1","first-page":"402","article-title":"Curative strategy for high\u2010risk smoldering myeloma (GEM\u2010CESAR): carfilzomib, Lenalidomide and dexamethasone (KRd) as induction followed by HDT\u2010ASCT, consolidation with Krd and maintenance with Rd","volume":"130","author":"Mateos M\u2010V","year":"2017","journal-title":"Blood"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.26590","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T18:01:17Z","timestamp":1692813677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.26590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,23]]},"references-count":187,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/ajh.26590"],"URL":"https:\/\/doi.org\/10.1002\/ajh.26590","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,23]]},"assertion":[{"value":"2022-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}