{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:27:19Z","timestamp":1792207639753,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23 HL141445"],"award-info":[{"award-number":["K23 HL141445"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10HL069294"],"award-info":[{"award-number":["U10HL069294"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early autologous hematopoietic cell transplantation (AHCT) with post\u2010transplant maintenance therapy is standard of care in multiple myeloma (MM). While short\u2010term quality of life (QOL) deterioration after AHCT is known, the long\u2010term trajectories and symptom burden after transplantation are largely unknown. Toward this goal, a secondary analysis of QOL data of the BMT CTN 0702, a randomized controlled trial comparing outcomes of three treatment interventions after a single AHCT (<jats:italic>N<\/jats:italic>\u00a0=\u00a0758), was conducted. FACT\u2010BMT scores up to 4\u2009years post\u2010AHCT were analyzed. Symptom burden was studied using responses to 17 individual symptoms dichotomized as \u2018none\/mild\u2019 for scores 0\u20132 and \u2018moderate\/severe\u2019 for scores of 3 or 4. Patients with no moderate\/severe symptom ratings were considered to have low symptom burden at 1\u2010year. Mean age at enrollment was 55.5\u2009years with 17% African Americans. Median follow\u2010up was 6\u2009years (range, 0.4\u20138.5\u2009years). FACT\u2010BMT scores improved between enrollment and 1\u2010year and remained stable thereafter. Low symptom burden was reported by 27% of patients at baseline, 38% at 1\u2010year, and 32% at 4\u2009years post\u2010AHCT. Predictors of low symptom burden at 1\u2010year included low symptom burden at baseline: OR 2.7 (1.8\u20134.1), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001; older age: OR 2.1 (1.3\u20133.2), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0007; and was related to being employed: OR 2.1 (1.4\u20133.2), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0004). We conclude that MM survivors who achieve disease control after AHCT have excellent recovery of FACT\u2010BMT and subscale scores to population norms by 1\u2010year post\u2010transplant, though many patients continue to report moderate to severe severity in some symptoms at 1\u2010year and beyond.<\/jats:p>","DOI":"10.1002\/ajh.26596","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T17:59:11Z","timestamp":1652551151000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Trajectories of quality of life recovery and symptom burden after autologous hematopoietic cell transplantation in multiple myeloma"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-5643","authenticated-orcid":false,"given":"Anita","family":"D'Souza","sequence":"first","affiliation":[{"name":"Department of Medicine Medical College of Wisconsin  Milwaukee 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