{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:11:58Z","timestamp":1792012318684,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["AWD00006066"],"award-info":[{"award-number":["AWD00006066"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001368","name":"V Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Multi\u2010agent induction chemotherapy (IC) improves response rates in younger patients with acute myeloid leukemia (AML); however, relapse remains the principal cause of treatment failure. Improved induction regimens are needed. A prospective single\u2010center phase Ib\/II study evaluating fludarabine, cytarabine, G\u2010CSF, and idarubicin combined with venetoclax (FLAG\u2010IDA\u2009+\u2009VEN) in patients with newly diagnosed (ND) or relapsed\/refractory AML. The primary efficacy endpoint was assessment of overall activity (overall response rate [ORR]: complete remission [CR]\u2009+\u2009CR with partial hematologic recovery [CRh]\u2009+\u2009CR with incomplete hematologic recovery [CRi]\u2009+\u2009morphologic leukemia free state\u2009+\u2009partial response). Secondary objectives included additional assessments of efficacy, overall survival (OS), and event\u2010free survival (EFS). Results of the expanded ND cohort with additional follow\u2010up are reported. Forty\u2010five patients (median age: 44\u2009years [range 20\u201365]) enrolled. ORR was 98% (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u200944\/45; 95% credible interval 89.9%\u201399.7%). Eighty\u2010nine percent (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u200940\/45) of patients attained a composite CR (CRc\u2009+\u2009CRh\u2009+\u2009CRi) including 93% (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u200937\/40) who were measurable residual disease (MRD) negative. Twenty\u2010seven (60%) patients transitioned to allogeneic stem cell transplant (alloHSCT). Common non\u2010hematologic adverse events included febrile neutropenia (44%;\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u200920), pneumonia (22%,\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u200910), bacteremia (18%,\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u20098), and skin\/soft tissue infections (44%,\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u200920). After a median follow\u2010up of 20\u2009months, median EFS and OS were not reached. Estimated 24\u2010month EFS and OS were 64% and 76%, respectively. FLAG\u2010IDA\u2009+\u2009VEN is an active regimen in ND\u2010AML capable of producing high MRD\u2010negative remission rates and enabling transition to alloHSCT when appropriate in most patients. Toxicities were as expected with IC and were manageable. Estimated 24\u2010month survival appears favorable compared to historical IC benchmarks.\n                  <\/jats:p>","DOI":"10.1002\/ajh.26601","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T07:34:52Z","timestamp":1652859292000},"page":"1035-1043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Venetoclax combined with\n                    <scp>FLAG\u2010IDA<\/scp>\n                    induction and consolidation in newly diagnosed acute myeloid leukemia"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9003-0390","authenticated-orcid":false,"given":"Courtney D.","family":"DiNardo","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas 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