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We performed a retrospective cohort study for patients with newly diagnosed cancer from 2011 to 2020 at Harris Health System, which cares for uninsured residents in the Houston metropolitan area. Patient demographics, NCI comorbidity index, area of deprivation index (ADI), cancer histology, staging, and systemic therapy data were extracted. CAT included overall venous thromboembolism (VTE) or pulmonary embolism +\/\u2212 lower extremity deep vein thrombosis (PE\/LE\u2010DVT) within 1\u2009year of diagnosis. We used multivariable Fine\u2010Gray models to assess the associations with CAT accounting for death as a competing risk. Among 15\u2009342 patients, 74% were uninsured and 84% lived in socioeconomically disadvantaged neighborhoods. There were 16% Non\u2010Hispanic White (NHW), 28% Non\u2010Hispanic Black (NHB), 50% Hispanic (27% Mexican), and 6% Asian\/Pacific Islanders (API). The 1\u2010year CAT incidence rate was 14.6%. Overall VTE was lower for Hispanics versus NHW (SHR 0.87 [0.76\u20130.99]) and API versus NHW (SHR 0.58 [0.44\u20130.77]). PE\/LE\u2010DVT was higher for NHB versus NHW (SHR 1.18 [1.01\u20131.39]). CAT was also associated with chemotherapy\u2010based regimens (+\/\u2212 immunotherapy), age, obesity, cancer type\/staging, VTE history, and recent hospitalization. NCI comorbidity and ADI scores were associated with mortality but not CAT. In a large cohort of underserved patients with cancer, we identified an elevated incidence of CAT with known and novel risk predictors. Hispanics had lower adjusted rates of CAT and mortality. Our findings highlight the need to investigate and incorporate vulnerable populations in clinical trials.<\/jats:p>","DOI":"10.1002\/ajh.26623","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T09:57:56Z","timestamp":1653991076000},"page":"1044-1054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Patterns of venous thromboembolism risk, treatment, and outcomes among patients with cancer from uninsured and vulnerable populations"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-4706","authenticated-orcid":false,"suffix":"Jr","given":"Wilson L.","family":"da Costa","sequence":"first","affiliation":[{"name":"Section of Epidemiology and Population Science Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Guffey","sequence":"additional","affiliation":[{"name":"Institute for Clinical &amp; Translational Research Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiodun","family":"Oluyomi","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Population Science Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raka","family":"Bandyo","sequence":"additional","affiliation":[{"name":"Tegria  Renton WA USA"},{"name":"Harris Health System  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-6447","authenticated-orcid":false,"given":"Omar","family":"Rosales","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Population Science Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney D.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Harris Health System  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Granada","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimrah","family":"Riaz","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"School of Biomedical Informatics The University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Division of Hematology University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Carrier","sequence":"additional","affiliation":[{"name":"Department of Medicine Ottawa Hospital Research Institute, University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher I.","family":"Amos","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Population Science Baylor College of Medicine  Houston Texas USA"},{"name":"Institute for Clinical &amp; Translational Research Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Flowers","sequence":"additional","affiliation":[{"name":"Department of Lymphoma\u2010Myeloma, Division of Cancer Medicine The University of Texas M D Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8455-2309","authenticated-orcid":false,"given":"Ang","family":"Li","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2021.03.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814468"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814630"},{"key":"e_1_2_8_5_1","first-page":"60","volume-title":"U. 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