{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:26:31Z","timestamp":1786976791030,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Intravascular lymphoma (IVL) is a rare extranodal non\u2010Hodgkin lymphoma. We performed a retrospective analysis of 55 IVL patients who were treated at our institution 2003\u20132018. Median age at diagnosis was 68\u2009years, and 64% were males. The most frequent presenting symptoms were skin rash 43% and weight loss 30%. MRI brain on IVL patients with CNS involvement (CNS\u2010IVL) showed multifocal involvement in 76% (13\/17). 89% (17\/19) of non\u2010CNS\u2010IVL patients with abnormal FDG\u2010PET had biopsy of an avid lesion resulting in definitive diagnosis. The top diagnostic biopsy site was the bone marrow (45%). 56% had multiorgan involvement. Based on CNS involvement, 36.5% (20\/55) had CNS\u2010IVL and 63.5% (35\/55) had non\u2010CNS\u2010IVL. CNS\u2010IVL group consists of clinically isolated CNS involvement (CNS\u2010only IVL) (22%;12\/55) and mixed clinical CNS and peripheral site involvement (M\u2010IVL) (14.5%; 8\/55). Non\u2010CNS\u2010IVL group consists of clinically isolated skin involvement (skin\u2010only IVL) (9%; 5\/55) and peripheral IVL with or without skin involvement (P\u2010IVL); (54.5%; 30\/55). Skin involvement was predominantly in the lower extremities. Pathologically, 89% (48\/54) were B\u2010cell IVL. Rituximab + high\u2010dose methotrexate\u2010based regimen were used in 75% (12\/16) of CNS\u2010IVL patients and RCHOP in 60% (17\/28) of non\u2010CNS\u2010IVL patients. Estimated 5\u2010year progression free survival (PFS) and overall survival (OS) for the entire cohort were 38.6% and 52%, respectively. Skin\u2010only IVL was associated with excellent survival. Platelet count &lt;150x10\n                    <jats:sup>9<\/jats:sup>\n                    \/L, age\u2009&gt;\u200960Y, and treatment without Rituximab were poor prognostic factors. Further research is necessary to identify novel therapies.\n                  <\/jats:p>","DOI":"10.1002\/ajh.26635","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T09:54:33Z","timestamp":1655459673000},"page":"1150-1158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical characteristics, prognostic indicators, and survival outcomes in intravascular lymphoma: Mayo Clinic experience (2003\u20132018)"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2739-7357","authenticated-orcid":false,"given":"Karan","family":"Seegobin","sequence":"first","affiliation":[{"name":"Department of Haematology and Medical Oncology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Statistics and Informatics Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamad","family":"Alhaj Moustafa","sequence":"additional","affiliation":[{"name":"Department of Haematology and Medical Oncology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umair","family":"Majeed","sequence":"additional","affiliation":[{"name":"Department of Haematology and Medical Oncology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology Mayo Clinic  Jacksonville Florida 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Ayala","sequence":"additional","affiliation":[{"name":"Department of Haematology and Medical Oncology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6752-5440","authenticated-orcid":false,"given":"Madiha","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Haematology and Medical Oncology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz S.","family":"Nowakowski","sequence":"additional","affiliation":[{"name":"Department of Haematology and Medical Oncology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3532-9132","authenticated-orcid":false,"given":"Thomas M.","family":"Habermann","sequence":"additional","affiliation":[{"name":"Department of 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