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The median duration of hematologic CR was 12.3\u2009years, and 45% of patients with a hematologic CR had no evidence of a recurrent plasma cell dyscrasia at 15\u2009years after HDM\/SCT. With a median follow\u2010up interval of 8\u2009years, the median event\u2010free survival (EFS) and overall survival (OS) were 3.3 and 7.6\u2009years, respectively. Patients with a hematologic CR had a median OS of 15\u2009years, and 30% of these patients survived &gt;20\u2009years. On multivariable analysis, dFLC &gt;180\u2009mg\/L and BM plasma cells &gt;10% were independently associated with shorter EFS, whereas BNP &gt;81\u2009pg\/mL, troponin I\u2009&gt;\u20090.1\u00a0ng\/mL, and serum creatinine &gt;2.0\u00a0mg\/dL were independently associated with shorter OS. We developed a prognostic score for EFS, which incorporated dFLC &gt;180\u2009mg\/L and BMPC% &gt;10% as adverse risk factors. Patients with low\u2010risk (0 factors), intermediate\u2010risk (1 factor), and high\u2010risk (2 factors) disease had median EFS estimates of 5.3, 2.8, and 1.0\u2009years, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). The 100\u2010day treatment\u2010related mortality rate was 3% in the latest treatment period (2012\u20132021), and the 25\u2010year risk of t\u2010MDS\/AML was 3%. We conclude that HDM\/SCT induces durable hematologic responses and prolonged survival with improved safety in selected patients with AL amyloidosis.<\/jats:p>","DOI":"10.1002\/ajh.26641","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T18:13:56Z","timestamp":1655921636000},"page":"1189-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Predictors of hematologic response and survival with stem cell transplantation in <scp>AL<\/scp> amyloidosis: A 25\u2010year longitudinal study"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-7669","authenticated-orcid":false,"given":"Joshua N.","family":"Gustine","sequence":"first","affiliation":[{"name":"Amyloidosis Center Boston University School of Medicine and Boston Medical Center  Boston Massachusetts 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