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We evaluated the effect of a third booster BNT162b2 vaccine on the kinetics of anti\u2010 SARS\u2010CoV\u20102 neutralizing antibody (NAbs) titers in patients with B\u2010cell malignancies. Patients with NHL (<jats:italic>n<\/jats:italic>\u00a0=\u00a054) Waldenstr\u00f6m's macroglobulinemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a090) and chronic lymphocytic leukemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a049) enrolled in the ongoing NCT04743388 study and compared against matched healthy controls. All patient groups had significantly lower NAbs compared to controls at all time points. 1\u2009month post the third dose (M1P3D) NAbs increased significantly compared to previous time points (median NAbs 77.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05 for all comparisons) in all patients. NAbs\u2009\u2265\u200950% were seen in 59.1% of patients, 34.5% of patients with suboptimal responses post\u2010second dose, elicited a protective NAb titer \u226550%. Active treatment, rituximab, and BTKi treatment were the most important prognostic factors for a poor NAb response at 1MP3D; only 25.8% of patients on active treatment had NAbs\u2009\u2265\u200950%. No significant between\u2010group differences were observed. Patients with B\u2010cell malignancies have inferior humoral responses against SARS\u2010CoV\u20102 and booster dose enhances the NAb response in a proportion of these patients.<\/jats:p>","DOI":"10.1002\/ajh.26669","type":"journal-article","created":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T11:04:00Z","timestamp":1658660640000},"page":"1300-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["SARS\u2010CoV\u20102 humoral responses following booster BNT162b2 vaccination in patients with B\u2010cell malignancies"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5133-1422","authenticated-orcid":false,"given":"Evangelos","family":"Terpos","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine, National and Kapodistrian University of Athens  Athens 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