{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:35:49Z","timestamp":1790908549943,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low\u2010dose dasatinib is safe and effective in patients with chronic myeloid leukemia in chronic phase (CML\u2010CP). No randomized trials have compared the outcome with standard\u2010dose dasatinib. This study aims to compare the outcome of patients with CML\u2010CP treated with frontline dasatinib 50 versus 100\u2009mg\/day. We analyzed 233 patients with newly diagnosed CML\u2010CP treated with low\u2010dose dasatinib (<jats:italic>N<\/jats:italic>\u00a0=\u00a083) or standard\u2010dose dasatinib (<jats:italic>N<\/jats:italic>\u00a0=\u00a0150). Propensity score analysis with 1:1 matching was performed and identified 77 patients in each cohort without significant baseline differences. Response rates were reported as the cumulative incidences of complete cytogenetic response, major molecular response (MMR), molecular response (MR)4, and MR4.5. Failure\u2010free survival (FFS), event\u2010free survival (EFS), transformation\u2010free survival (TFS), and overall survival (OS) were also compared. Patients on low\u2010dose dasatinib with suboptimal response by European LeukemiaNet (ELN) 2013 criteria had the option to increase the dose to 100\u2009mg\/day. The overall median follow\u2010up time was 60\u2009months. The 3\u2010year MMR rates were 92% and 84% for low\u2010dose and standard\u2010dose dasatinib, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.23). Dasatinib 50\u2009mg\/day induced higher cumulative incidence of MR4 (77% vs. 66%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04) and MR4.5 (77% vs. 62%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) at 3\u2009years. The 4\u2010year FFS, EFS and OS rates were 89% versus 77% (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.04), 95% versus 92% (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.06), and 97% versus 96% (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.78) with low\u2010dose and standard\u2010dose dasatinib, respectively. The rate of any grade pleural effusion was 5% with dasatinib 50\u2009mg\/day compared to 21% with 100\u2009mg\/day. Dasatinib 50\u2009mg\/day is at least as effective as 100\u2009mg\/day with a better safety profile and drug exposure.<\/jats:p>","DOI":"10.1002\/ajh.26689","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T16:30:00Z","timestamp":1660408200000},"page":"1413-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Low\u2010dose dasatinib 50\u2009mg\/day versus standard\u2010dose dasatinib 100\u2009mg\/day as frontline therapy in chronic myeloid leukemia in chronic phase: A propensity score analysis"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4465-6119","authenticated-orcid":false,"given":"Elias","family":"Jabbour","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas 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Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-2482","authenticated-orcid":false,"given":"Guillermo","family":"Garcia\u2010Manero","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7679-6453","authenticated-orcid":false,"given":"Gautam","family":"Borthakur","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas 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