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We report our clinic's experience converting 36 patients with sickle cell disease (SCD) from full agonist opioids to buprenorphine using a method developed in the past 10\u2009years. Thirty of these patients were induced using a standard outpatient protocol and six were induced during medical admissions. Typically, patients were on high\u2010dose chronic opioid therapy (COT) with inadequate response, and often with very high acute care utilization. Unlike prior case series, the method of induction, dosing, and management of withdrawal are detailed, as are post\u2010induction adverse events. There were seven adverse events in the first 3\u2009days following standard induction, and two of which were judged to be definitely related to the induction but none with any lasting sequelae. At 6\u2009months follow\u2010up, five participants had discontinued buprenorphine (16.67%), and overall acute care visits dropped from a mean of 10.50 (SD 11.35) in the 6\u2009months pre\u2010induction to 2.89 (SD 3.40) in the 6\u2009months post\u2010induction. In an appropriately interdisciplinary care setting, buprenorphine shows promise as a safe alternative to COT with early evidence of benefit for high\u2010utilizing patients with SCD.<\/jats:p>","DOI":"10.1002\/ajh.26699","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T05:38:30Z","timestamp":1661578710000},"page":"1435-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Converting adults with sickle cell disease from full agonist opioids to buprenorphine: A reliable method with safety and early evidence of reduced acute care utilization"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2422-2452","authenticated-orcid":false,"given":"Mandy S.","family":"David","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematology The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Lauriello","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ijeoma","family":"Nnake","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Plazas Montana","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyra","family":"Lasko","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Maryland Medical System  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Buri\u2010Nagua","sequence":"additional","affiliation":[{"name":"Johns Hopkins University, Homewood Campus  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yetunde","family":"Olagbaju","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Sears","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Salzberg","sequence":"additional","affiliation":[{"name":"University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie M.","family":"Lanzkron","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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