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Nodular sclerosis, mixed cellularity, lymphocyte depletion, and lymphocyte\u2010rich HL are subgroups of classical HL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Risk Stratification<\/jats:title><jats:p>An accurate assessment of the stage of disease in patients with HL is critical for the selection of the appropriate therapy. Prognostic models that identify patients at low or high risk for recurrence, as well as the response to therapy as determined by positron emission tomography scan, are used to optimize therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Risk\u2010Adapted Therapy<\/jats:title><jats:p>Initial therapy for HL patients is based on the histology of the disease, the anatomical stage, and the presence of poor prognostic features. Patients with early\u2010stage disease are typically treated with combined modality strategies utilizing abbreviated courses of combination chemotherapy followed by involved\u2010field radiation therapy, while those with advanced\u2010stage disease receive a longer course of chemotherapy, often without radiation therapy. However, newer agents, including brentuximab vedotin and anti\u2010programmed death\u20101 (PD\u20101) antibodies, are now being incorporated into frontline therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Management of Relapsed\/Refractory Disease<\/jats:title><jats:p>High\u2010dose chemotherapy (HDCT) followed by an autologous stem cell transplant (ASCT) is the standard of care for most patients who relapse following initial therapy. 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