{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:37:52Z","timestamp":1789756672234,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K08517"],"award-info":[{"award-number":["22K08517"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We analyzed a Japanese registry database to elucidate the incidence, risk factors, and outcomes of adenovirus (AdV) disease after autologous and allogeneic hematopoietic cell transplantation (HCT) in contemporary real\u2010world patients. We evaluated the cumulative incidence of AdV disease, as well as risk factors, survival, and treatment details, among 25\u2009233 patients who underwent autologous HCT and 48\u2009380 patients who underwent allogeneic HCT between 2005 and 2019. The 1\u2010year cumulative incidences of AdV disease after autologous and allogeneic HCT were 0.18% and 1.52%, respectively, in children, and 0.49% and 2.99%, respectively, in adults. Among patients with AdV disease, renourinary infection was the most common manifestation, and viremia or disseminated disease occurred in 6% of those after autologous HCT and 19% of those after allogeneic HCT. In multivariate analysis, age \u226550\u2009years and lymphoma were associated with AdV disease after autologous HCT, while patients age \u226550\u2009years, male patients, lymphoma, HCT\u2010specific comorbidity index \u22653, human leukocyte antigen\u2010mismatched or haploidentical donors, cord blood, in vivo T\u2010cell depletion, HCT from 2005 to 2009, acute graft\u2010versus\u2010host disease (GVHD), and chronic GVHD were associated with AdV disease after allogeneic HCT. The 1\u2010year probabilities of survival after disease diagnosis were 65% in autologous HCT and 44% in allogeneic HCT. Regardless of the AdV disease burden, there was an increased risk of mortality after both autologous and allogeneic HCT. The most commonly used antiviral agents were cidofovir and vidarabine. The probabilities of improvement and survival with currently available agents were suboptimal. AdV disease after HCT remains a challenge. Better antiviral modalities are necessary.<\/jats:p>","DOI":"10.1002\/ajh.26723","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T12:53:11Z","timestamp":1662814391000},"page":"1568-1579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Adenovirus disease after hematopoietic cell transplantation: A Japanese transplant registry analysis"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4881-0427","authenticated-orcid":false,"given":"Yoshihiro","family":"Inamoto","sequence":"first","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo 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