{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:26:36Z","timestamp":1787765196869,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["CA016672"],"award-info":[{"award-number":["CA016672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"Abstract<\/jats:title>\n \n RUNX1<\/jats:italic>\n \u2010mutated (m\n RUNX1)<\/jats:italic>\n acute myeloid leukemia (AML) has historically been associated with poor outcomes in the setting of conventional chemotherapy. The prognostic impact of m\n RUNX1<\/jats:italic>\n AML is not well\u2010established in the current era of lower\u2010intensity treatment regimens incorporating venetoclax. We retrospectively analyzed 907 patients with newly diagnosed AML, including 137 patients with m\n RUNX1<\/jats:italic>\n AML, who underwent first\u2010line therapy with intensive chemotherapy (IC), low\u2010intensity therapy without venetoclax (LIT without VEN), or LIT with VEN. When stratified by\n RUNX1<\/jats:italic>\n status, there was no statistically significant difference in outcomes between m\n RUNX1<\/jats:italic>\n and wild\u2010type (wt\n RUNX1<\/jats:italic>\n ) AML, regardless of therapy received. However, among patients who received LIT with VEN, there was a trend towards superior overall survival (OS) in those with m\n RUNX1<\/jats:italic>\n AML (median OS for m\n RUNX1<\/jats:italic>\n vs. wt\n RUNX1:<\/jats:italic>\n 25.1 vs. 11.3\u2009months; 2\u2010year OS 54% vs. 33%;\n p<\/jats:italic>\n \u00a0=\u20090.12). In patients without another adverse\u2010risk cyto\u2010molecular feature, the presence of m\n RUNX1<\/jats:italic>\n conferred inferior OS in patients who received IC (\n p<\/jats:italic>\n \u00a0=\u20090.02) or LIT without VEN (\n p<\/jats:italic>\n \u00a0=\u20090.003) but not in those who received LIT with VEN\n (<\/jats:italic>\n m\n RUNX1<\/jats:italic>\n vs. wt\n RUNX1:<\/jats:italic>\n 25.1 vs. 30.0\u00a0months; 2\u2010year OS 59% vs. 54%;\n p<\/jats:italic>\n \u00a0=\u20090.86). A multivariate analysis showed possible interaction between\n RUNX1<\/jats:italic>\n mutation status and treatment, suggesting a differential prognostic impact of\n RUNX1<\/jats:italic>\n mutations when patients received IC versus LIT with VEN. In summary, the prognostic impact of m\n RUNX1<\/jats:italic>\n AML may be treatment\u2010dependent, and the presence of\n RUNX1<\/jats:italic>\n mutations may not impact clinical outcomes when venetoclax\u2010based regimens are used.\n <\/jats:p>","DOI":"10.1002\/ajh.26724","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T09:42:57Z","timestamp":1662802977000},"page":"1560-1567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Differential prognostic impact of\n \n RUNX1<\/i>\n <\/scp>\n mutations according to frontline therapy in patients with acute myeloid leukemia"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8641-6415","authenticated-orcid":false,"given":"Sangeetha","family":"Venugopal","sequence":"first","affiliation":[{"name":"Departments of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7621-377X","authenticated-orcid":false,"given":"Farhad","family":"Ravandi","sequence":"additional","affiliation":[{"name":"Departments of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-2212","authenticated-orcid":false,"given":"Marina","family":"Konopleva","sequence":"additional","affiliation":[{"name":"Departments of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9892-9832","authenticated-orcid":false,"given":"Tapan","family":"Kadia","sequence":"additional","affiliation":[{"name":"Departments of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-5176","authenticated-orcid":false,"given":"Guillermo","family":"Montalban\u2010Bravo","sequence":"additional","affiliation":[{"name":"Departments of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-4895","authenticated-orcid":false,"given":"Musa","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Departments of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyur P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Departments of Hematopathology, and The University of Texas MD Anderson Cancer Center Houston Texas 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