{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:34:11Z","timestamp":1784543651446,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:00:00Z","timestamp":1666569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with multiple myeloma (MM) have a lower efficacy from COVID\u201019 vaccination and a high rate of mortality from COVID\u201019 in hospitalized patients. However, the overall rate and severity of COVID\u201019 infection in all settings (including non\u2010hospitalized patients) and the independent impact of plasma cell\u2010directed therapies on outcomes needs further study. We reviewed the medical records of 9225 patients with MM or AL amyloidosis (AL) seen at Mayo Clinic Rochester, Arizona, and Florida between 12\/01\/2019 and 8\/31\/2021 and identified 187 patients with a COVID\u201019 infection (<jats:italic>n<\/jats:italic>\u00a0=\u2009174\u2009MM, <jats:italic>n<\/jats:italic>\u00a0=\u200913 AL). The infection rate in our cohort was relatively low at 2% but one\u2010fourth of the COVID\u201019 infections were severe. Nineteen (10%) patients required intensive care unit (ICU) admission and 5 (3%) patients required mechanical ventilation. The mortality rate among hospitalized patients with COVID\u201019 was 22% (16\/72 patients). Among patients that were fully vaccinated at the time of infection (<jats:italic>n<\/jats:italic>\u00a0=\u200912), two (17%) developed severe COVID\u201019 infection, without any COVID\u2010related death. On multivariable analysis, treatment with CD38 antibody within 6\u00a0months of COVID\u201019 infection [Risk ratio (RR) 3.6 (95% CI: 1.2, 10.5), <jats:italic>p<\/jats:italic>\u00a0=\u2009.02], cardiac [RR 4.1 (95% CI: 1.3, 12.4), <jats:italic>p<\/jats:italic>\u00a0=\u2009.014] or pulmonary comorbidities [RR 3.6 (95% CI 1.1, 11.6); <jats:italic>p<\/jats:italic>\u00a0=\u2009.029] were independent predictors for ICU admission. Cardiac comorbidity [RR 2.6 (95% CI: 1.1, 6.5), <jats:italic>p<\/jats:italic>\u00a0=\u2009.038] was an independent predictor of mortality whereas MM\/AL in remission was associated with lower mortality [RR 0.4 (95% CI: 0.2\u20130.8); <jats:italic>p<\/jats:italic>\u00a0=\u2009.008].<\/jats:p>","DOI":"10.1002\/ajh.26762","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T07:54:07Z","timestamp":1665647647000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Risk factors for severe infection and mortality In patients with <scp>COVID<\/scp>\u201019 in patients with multiple myeloma and <scp>AL<\/scp> amyloidosis"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7937-1557","authenticated-orcid":false,"given":"Matthew","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester 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