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Although treatment with several drugs has shown improved disease control, allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) remains the only curative treatment for MDS. The number of patients receiving a transplant, as well as survival, have increased past years because of the use of reduce\u2010intensity conditioning regimens (RIC) as well as the use of haploidentical donors for transplantation. With treatment\u2010related mortality as main limitation, pre\u2010transplant evaluation is essential to assess risks for this older group of patients. In a recent randomized study, allo\u2010HSCT with RIC for patients &gt;50\u2009years old with higher\u2010risk MDS demonstrated superiority in survival compared with hypomethylating agents. Genetic mutations have been shown to significantly impact treatment outcomes including after transplant. Recently, a transplant\u2010specific risk score (which includes age, donor type, performance status, cytogenetic category, recipient's cytomegalovirus status, percentage of blasts, and platelet count) has shown superiority in transplantation outcome prediction, compared with previous scoring systems. Survival remains low for most patients with\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations and novel treatment strategies are needed, such as administration of natural killer cells post\u2010transplant, as there is no clear evidence that maintenance therapy after transplantation can improve outcomes.\n                  <\/jats:p>","DOI":"10.1002\/ajh.26763","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T11:53:02Z","timestamp":1666007582000},"page":"322-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Allogeneic stem cell transplantation for patients with myelodysplastic syndromes"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1131-5564","authenticated-orcid":false,"given":"Pongthep","family":"Vittayawacharin","sequence":"first","affiliation":[{"name":"Hematopoietic Stem Cell Transplantation and Cellular Therapy Program, Division of Hematology\/Oncology, Department of Medicine University of California Irvine  Irvine California USA"},{"name":"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2130-7645","authenticated-orcid":false,"given":"Piyanuch","family":"Kongtim","sequence":"additional","affiliation":[{"name":"Hematopoietic Stem Cell Transplantation and Cellular Therapy Program, Division of Hematology\/Oncology, Department of Medicine University of California Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan O.","family":"Ciurea","sequence":"additional","affiliation":[{"name":"Hematopoietic Stem Cell Transplantation and Cellular Therapy Program, Division of Hematology\/Oncology, Department of Medicine University of California Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.1175"},{"key":"e_1_2_17_4_1","unstructured":"AulettaJ.J.KJ ChenM. 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