{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:52:33Z","timestamp":1792212753991,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with relapsed\/refractory (R\/R) higher\u2010risk myelodysplastic syndromes (MDS) have a dismal median overall survival (OS) after failing hypomethylating agent (HMA) treatment. There is no standard of care for patients after HMA therapy failure; hence, there is a critical need for effective therapeutic strategies. Herein, we present the safety and efficacy of venetoclax\u2009+\u2009azacitidine in patients with R\/R MDS. This phase 1b, open\u2010label, multicenter study enrolled patients \u226518\u2009years. Patients were treated with escalating doses of oral venetoclax: 100, 200, or 400\u2009mg daily for 14\u2009days every 28\u2010day cycle. Azacitidine was administered on Days 1\u20137 every cycle at 75\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/day intravenously\/subcutaneously. Responses were assessed per modified 2006 International Working Group (IWG) criteria. Forty\u2010four patients (male 86%, median age 74\u2009years) received venetoclax\u2009+\u2009azacitidine treatment. Median follow\u2010up was 21.2\u00a0months. Hematological adverse events of Grade\u2009\u2265\u20093 included febrile neutropenia (34%), thrombocytopenia (32%), neutropenia (27%), and anemia (18%). Pneumonia (23%) was the most common Grade\u2009\u2265\u20093 infection. Marrow responses were seen including complete remission (CR,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20093, 7%) and marrow CR (mCR,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200914, 32%); 36% (16\/44) achieved transfusion independence (TI) for RBCs and\/or platelets, and 43% (6\/14) with mCR achieved hematological improvement (HI). The median time to CR\/mCR was 1.2\u00a0months, and the median duration of response for CR\u2009+\u2009mCR was 8.6\u00a0months. Median OS was 12.6\u00a0months. Venetoclax\u2009+\u2009azacitidine shows activity in patients with R\/R MDS following prior HMA therapy failure and provides clinically meaningful benefits, including HI and TI, and encouraging OS.\n                  <\/jats:p>","DOI":"10.1002\/ajh.26771","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T14:18:40Z","timestamp":1667139520000},"page":"272-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["A phase 1b study of venetoclax and azacitidine combination in patients with relapsed or refractory myelodysplastic syndromes"],"prefix":"10.1002","volume":"98","author":[{"given":"Amer M.","family":"Zeidan","sequence":"first","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale University and Yale Cancer Center  New Haven Connecticut 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Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravitharan","family":"Krishnadasan","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Arizona Cancer Center  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Bajel","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology Peter MacCallum Cancer Center and The Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Research and Development Genentech Inc  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuhong","family":"Zha","sequence":"additional","affiliation":[{"name":"Research and Development AbbVie Inc  North Chicago Illinois 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