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However, its prognostic value remains unclear in the era of novel agents. Here, we retrospectively analyzed the impact of +1q on the outcomes of 934 patients newly diagnosed with MM. +1q was identified in 53.1% of patients and verified as an independent variate for inferior overall survival (OS) (hazard ratio, 1.400; 95% confidence interval, 1.097\u20131.787; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007). Concurrence of other HRCAs (particularly t(14;16) and del(17p)) further exacerbated the outcomes of patients with +1q, suggesting prognostic heterogeneity. Thus, a risk\u2010scoring algorithm based on four risk variates (t(14;16), hypercalcemia, ISS III, and high LDH) was developed to estimate the outcomes of patients with +1q. Of the patients, 376 evaluable patients with +1q were re\u2010stratified into low (31.6%), intermediate (61.7%), and high risk (6.7%) groups, with significantly different progression\u2010free survival and OS (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), in association with early relapse of the disease. The prognostic value of this model was validated in the CoMMpass cohort. While attaining undetectable MRD largely circumvented the adverse impact of +1q, it scarcely ameliorated the outcome of the patients with high risk, who likely represent a subset of patients with extremely poor survival. Hence, patients with +1q are a heterogeneous group of high\u2010risk patients, therefore underlining the necessity for their re\u2010stratification. The proposed simple risk\u2010scoring model can estimate the outcomes of patients with +1q, which may help guide risk\u2010adapted treatment for such patients.<\/jats:p>","DOI":"10.1002\/ajh.26774","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T18:28:01Z","timestamp":1667154481000},"page":"251-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Proposed risk\u2010scoring model for estimating the prognostic impact of 1q gain in patients with newly diagnosed multiple myeloma"],"prefix":"10.1002","volume":"98","author":[{"given":"Peiyu","family":"Yang","sequence":"first","affiliation":[{"name":"Hematology Department First Hospital of Jilin University  Changchun Jilin China"},{"name":"Laboratory of Cancer Precision Medicine First Hospital of Jilin University  Changchun Jilin 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