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In the analysis of 716 patients with MDS diagnosed according to the 2016 WHO classification, we found that 75.3% of patients remained in the MDS group based on the ICC, while 24.7% of patients were reclassified to the MDS\/AML group after the exclusion of 15 patients who were classified to the AML group. Patients with MDS\/AML showed a distinct mutational landscape and had poorer outcomes, compared to those with MDS. In the MDS group, patients with MDS\u2010<jats:italic>SF3B1<\/jats:italic> had higher frequencies of <jats:italic>DNMT3A<\/jats:italic> and <jats:italic>TET2<\/jats:italic> mutations than those with MDS, not otherwise specified, with single lineage dysplasia or multilineage dysplasia. Patients with mutated <jats:italic>TP53<\/jats:italic> were associated with dismal outcomes, irrespective of the blast percentage. In conclusion, this study showed that the ICC facilitates efficient segregation and risk\u2010stratification of MDS which can help guide the treatment choice of patients with the disease.<\/jats:p>","DOI":"10.1002\/ajh.26799","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T07:05:26Z","timestamp":1672643126000},"page":"398-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinico\u2010genetic and prognostic analyses of 716 patients with primary <scp>myelodysplastic syndrome<\/scp> and <scp>myelodysplastic syndrome\/acute myeloid leukemia<\/scp> based on the 2022 International Consensus Classification"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4795-9844","authenticated-orcid":false,"given":"Wan\u2010Hsuan","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine National Taiwan 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