{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:22:56Z","timestamp":1789010576872,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R321\u2010A17536"],"award-info":[{"award-number":["R321\u2010A17536"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral T\u2010Cell Lymphomas (PTCLs) are rare, aggressive lymphomas with poor outcomes, but limited\u2010stage disease is infrequent and not well\u2010described. This study reports outcomes and prognostic factors in limited\u2010stage nodal PTCLs in a binational population\u2010based setting. Patients were identified from the Danish and Swedish lymphoma registries. Adults diagnosed with limited\u2010stage nodal PTCL (stage I\u2010II) and treated with CHOP(\u2212like) therapy \u00b1radiotherapy between 2000 and 2014 were included. Medical records were reviewed by local investigators. A total of 239 patients with a median age of 62\u2009years were included; 67% received 6\u20138\u00a0cycles of CHOP(\u2212like) therapy and 22% received 3\u20134\u00a0cycles, of which 59% also received radiotherapy. Autologous stem cell transplant consolidation was administered to 16% of all patients. Median follow\u2010up was 127\u2009months with 5\u2010years overall survival (OS) of 58% (95% CI: 53\u201365) and progression\u2010free survival (PFS) of 53% (95% CI: 47\u201359). In multivariable analysis, age\u2009\u2265\u200960\u2009years and B\u2010symptoms were unfavorable and ALK+ anaplastic large cell T\u2010Cell lymphoma was favorable for survival outcomes. There was no difference in treatment\u2010specific outcome (3\u20134\u00a0cycles vs. 6\u20138\u00a0cycles of CHOP(\u2212like)\u2009\u00b1\u2009radiotherapy). Low\u2010risk patients (age\u2009&lt;\u200960 without B\u2010symptoms) had a 5\u2010year OS of 77% (95% CI 67\u201389%). In the present study of limited\u2010stage nodal PTCL, survival after curative intent chemotherapy +\/\u2212 radiotherapy was inferior to that of limited\u2010stage diffuse large B\u2010cell lymphoma, but a subgroup of young patients without B\u2010symptoms had very good outcomes. Treatment outcomes after 3\u20134\u00a0cycles versus 6\u20138\u00a0cycles of CHOP(\u2212like) therapy were comparable.<\/jats:p>","DOI":"10.1002\/ajh.26803","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T06:54:47Z","timestamp":1672642487000},"page":"388-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Outcome of limited\u2010stage peripheral <scp>T\u2010Cell<\/scp> lymphoma after <scp>CHOP<\/scp>(\u2212like) therapy: A population based study of 239 patients from the Nordic lymphoma epidemiology group"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-0421","authenticated-orcid":false,"given":"Ahmed","family":"Ludvigsen Al\u2010Mashhadi","sequence":"first","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Centre Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg 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