{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:59:46Z","timestamp":1789041586736,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical trials of novel salvage therapies have encouraging outcomes for relapsed\/refractory transplant\u2010eligible classic Hodgkin lymphoma (R\/R cHL) but comparison with conventional chemotherapy is lacking. Herein, we report the final analysis of a multicenter retrospective cohort of R\/R cHL assessing outcomes by type of salvage therapy before autologous stem cell transplant (ASCT). R\/R cHL patients who underwent ASCT at 14 institutions across the United States were included. Outcomes were compared among patients receiving conventional chemotherapy, brentuximab vedotin (BV)\u2009+\u2009chemotherapy, BV alone, and a checkpoint inhibitor (CPI)\u2010based regimens before ASCT. Study endpoints included event\u2010free survival (EFS), progression\u2010free survival (PFS), and overall survival (OS). All endpoints are defined from relapse. Of 936 patients, 728 received conventional chemotherapy, 73 received BV\u2009+\u2009chemotherapy, 70 received BV alone, and 65 received CPI\u2010based regimens prior to ASCT. When adjusted for time to relapse, pre\u2010ASCT response and use of BV maintenance, patients receiving CPI\u2010based regimens had superior 2\u2010year EFS compared to conventional chemotherapy, BV\u2009+\u2009chemotherapy, and BV alone (79.7, 49.6, 62.3, and 36.9%, respectively, <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.0001). Among 649 patients transplanted after 1 line of salvage therapy, CPI\u2010based regimens were associated with superior 2\u2010year PFS compared to conventional chemotherapy (98% vs. 68.8%, hazard ratio: 0.1, 95% confidence interval: 0.03\u20130.5, <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.0001). OS did not differ by pre\u2010ASCT salvage regimen. In this large multicenter retrospective study, CPI\u2010based regimens improved EFS and PFS compared to other salvage regimens independent of pre\u2010ASCT response. These data support earlier sequencing of CPI\u2010based regimens in R\/R cHL in the pre\u2010ASCT setting.<\/jats:p>","DOI":"10.1002\/ajh.26827","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T10:59:54Z","timestamp":1673434794000},"page":"464-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Checkpoint inhibitor\u2010based salvage regimens prior to autologous stem cell transplant improve event\u2010free survival in relapsed\/refractory classic Hodgkin lymphoma"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7892-2625","authenticated-orcid":false,"given":"Sanjal H.","family":"Desai","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Hematology, Oncology and Transplantation University of Minnesota  Minneapolis 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of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-5177","authenticated-orcid":false,"given":"Gaurav","family":"Goyal","sequence":"additional","affiliation":[{"name":"O'Neal Comprehensive Cancer Center University of Alabama  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Kahl","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Dorritie","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology UPMC Hillman Cancer Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Azzi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Icahn 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