{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:06:22Z","timestamp":1792173982642,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Allogeneic hematopoietic cell transplant (allo\u2010HCT) provides the only potential route to long\u2010term remission in patients diagnosed with blast phase transformation of myeloproliferative neoplasm (BP\u2010MPN). We report on a large, retrospective European Society for Blood and Marrow Transplantation registry\u2010based study of BP\u2010MPN patients undergoing allo\u2010HCT. BP\u2010MPN patients undergoing first allo\u2010HCT between 2005 and 2019 were included. A total of 663 patients were included. With a median follow\u2010up of 62\u2009months, the estimated 3\u2010year overall survival (OS) was 36% (95% confidence interval [CI], 32\u201336). Factors associated with lower OS were Karnofsky Performance Score (KPS) &lt;90 (hazard ratio [HR] 1.65,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001) and active disease at allo\u2010HCT (HR 1.45,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001), whereas patients undergoing allo\u2010HCT more recently associated with a higher OS (HR 0.96,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.008). In a selected patient's population, the 3\u2010year OS of patients undergoing allo\u2010HCT in complete response (CR) and with a KPS \u226590 was 60%. KPS\u2009&lt;\u200990 (HR 1.4,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.001) and active disease (HR 1.44,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.0004) were associated with a lower progression\u2010free survival (PFS). Conversely, most recent allo\u2010HCT associated with a higher PFS (HR 0.96,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.008). Active disease at allo\u2010HCT (HR 1.34,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.03) was associated with a higher cumulative incidence of relapse (RI) and allo\u2010HCT in earlier calendar years (HR 0.96,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.02) associated with a lower RI. Last, KPS\u2009&lt;\u200990 (HR 1.91,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001), active disease (HR 1.74,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.003) and allo\u2010HCT from mismatched related donors were associated with a higher non\u2010relapse mortality (HR 2.66,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.003). In this large series of BP\u2010MPN patients, about one third were alive at 3\u2009years after transplantation. Patients undergoing allo\u2010HCT in the more recent era, with a KPS \u226590 and in CR at transplant had a better prognosis.\n                  <\/jats:p>","DOI":"10.1002\/ajh.26833","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T07:58:26Z","timestamp":1672991906000},"page":"628-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Outcomes after allogeneic hematopoietic cell transplant in patients diagnosed with blast phase of myeloproliferative neoplasms: A retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7889-5807","authenticated-orcid":false,"given":"Guillermo","family":"Ort\u00ed","sequence":"first","affiliation":[{"name":"Department of Hematology Vall d'Hebron University Hospital, Vall d'Hebron Institute of 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