{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:52:24Z","timestamp":1772826744795,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patient\u2010reported outcomes in AL amyloidosis have not been well\u2010studied. We analyzed health\u2010related quality of life (HRQOL) and AL amyloidosis symptoms data from the phase 3 TOURMALINE\u2010AL1 trial (NCT01659658) (ixazomib\u2010dexamethasone, <jats:italic>n<\/jats:italic>\u00a0=\u00a085; physician's choice of chemotherapy [PC], <jats:italic>n<\/jats:italic>\u00a0=\u00a083). HRQOL and symptom burden were measured with the SF\u201036v2, Functional Assessment of Cancer Therapy\/Gynecologic Oncology Group Neurotoxicity subscale (FACT\/GOG\u2010Ntx), and an amyloidosis symptom questionnaire (ASQ). Score changes during treatment were analyzed descriptively and using repeated\u2010measures linear mixed models; analyses were not adjusted for multiplicity. Least\u2010squares (LS) mean changes from baseline were significantly higher (better HRQOL) for ixazomib\u2010dexamethasone at several cycles for SF\u201036v2 Role Physical and Vitality subscales (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05); no subscales demonstrated significant differences favoring PC. For FACT\/GOG\u2010Ntx, small but significant differences in LS mean changes favored ixazomib\u2010dexamethasone over PC at multiple cycles for seven items and both summary scores; significant differences favored PC for one item (trouble hearing) at multiple cycles. ASQ total score trended downward (lower burden) in both arms; significant LS mean differences favored ixazomib\u2010dexamethasone over PC at some cycles (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Patients with relapsed\/refractory AL amyloidosis treated with ixazomib\u2010dexamethasone experienced HRQOL and symptoms that were similar to or trended better than patients treated with PC despite longer duration of therapy.<\/jats:p>","DOI":"10.1002\/ajh.26866","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T16:03:09Z","timestamp":1674921789000},"page":"720-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quality of life and symptoms among patients with relapsed\/refractory <scp>AL<\/scp> amyloidosis treated with <scp>ixazomib\u2010dexamethasone<\/scp> versus physician's choice"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-2445","authenticated-orcid":false,"given":"Vaishali","family":"Sanchorawala","sequence":"first","affiliation":[{"name":"Amyloidosis Center Boston University School of Medicine and Boston Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashutosh D.","family":"Wechalekar","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, Royal Free London NHS Foundation Trust University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kihyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan O.","family":"Sch\u00f6nland","sequence":"additional","affiliation":[{"name":"Department of Medicine V (Hematology, Oncology and Rheumatology), Amyloidosis Center Heidelberg Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather J.","family":"Landau","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Kwok","sequence":"additional","affiliation":[{"name":"Clinical Haematology Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Hematology Japanese Red Cross Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-9512","authenticated-orcid":false,"given":"Angela","family":"Dispenzieri","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaolo","family":"Merlini","sequence":"additional","affiliation":[{"name":"Amyloidosis Research and Treatment Center, Foundation IRCCS Policlinico San Matteo, Department of Molecular Medicine University of Pavia  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond L.","family":"Comenzo","sequence":"additional","affiliation":[{"name":"John C. Davis Myeloma and Amyloid Program Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dasha","family":"Cherepanov","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas, Inc. (TDCA)  Lexington Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa C.","family":"Hayden","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas, Inc. (TDCA)  Lexington Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Kumar","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas, Inc. (TDCA)  Lexington Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Labotka","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas, Inc. (TDCA)  Lexington Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas V.","family":"Faller","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas, Inc. (TDCA)  Lexington Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstathios","family":"Kastritis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010018\u20100034\u20103"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018016402"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.7.1817.1817"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2021.1890023"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028631"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2015.1102131"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2017.1297930"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010021\u201001317\u2010y"},{"key":"e_1_2_10_10_1","volume-title":"User's Manual for the SF36v2 Health Survey","author":"Maruish M","year":"2011"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41687\u2010017\u20100020\u20107"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101438.2003.13603.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.5609.5609"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102004\u201001\u20100089"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26536"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010014\u20102892\u2010z"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010018\u20100810\u2010x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.26866","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T13:17:15Z","timestamp":1706534235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.26866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/ajh.26866"],"URL":"https:\/\/doi.org\/10.1002\/ajh.26866","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,14]]},"assertion":[{"value":"2022-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}