{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:13:26Z","timestamp":1787883206237,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anemia of inflammation (AI) is frequently present in subjects with inflammatory disorders, primarily caused by inflammation\u2010driven iron retention in macrophages. So far, only limited data on qualitative and quantitative estimates of tissue iron retention in AI patients exist. We performed a prospective cohort study analyzing splenic, hepatic, pancreatic, and cardiac iron content with MRI\u2010based R2*\u2010relaxometry in AI patients, including subjects with concomitant true iron deficiency (AI+IDA) hospitalized between 05\/2020\u201301\/2022. Control groups were individuals without inflammation. Spleen R2* values in AI patients with ferritin \u2264200\u2009\u03bcg\/L (AI+IDA) were comparable with those found in controls. In AI patients with ferritin &gt;200\u2009\u03bcg\/L, spleen (47.6\u00a0s<jats:sup>\u22121<\/jats:sup> vs. 19.3\u2009s<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and pancreatic R2* values (32.5\u00a0s<jats:sup>\u22121<\/jats:sup> vs. 24.9\u2009s<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.011) were significantly higher compared with controls, while liver and heart R2*\u2010values did not differ. Higher spleen R2* values were associated with higher ferritin, hepcidin, CRP, and IL\u20106 concentrations. Spleen R2* values normalized in AI patients after recovery (23.6\u00a0s<jats:sup>\u22121<\/jats:sup> vs. 47.6\u2009s<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008), while no changes were found in patients with baseline AI+IDA. This is the first study investigating tissue iron distribution in patients with inflammatory anemia and AI with concomitant true iron deficiency. The results support the findings in animal models demonstrating iron retention in macrophages, which are primarily accumulating in the spleen under inflammatory conditions. MRI\u2010related iron measurement may help to better characterize actual iron needs and to define better biomarker thresholds in the diagnosis of true ID in patients with AI. It may qualify as a useful diagnostic method to estimate the need for iron supplementation and to guide therapy.<\/jats:p>","DOI":"10.1002\/ajh.26909","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T14:44:26Z","timestamp":1678200266000},"page":"890-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tissue iron distribution in patients with anemia of inflammation: Results of a pilot study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7849-2971","authenticated-orcid":false,"given":"Lukas","family":"Lanser","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Plaikner","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical University of Innsbruck  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