{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:48:24Z","timestamp":1790938104126,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There is a paucity of large\u2010scale data delineating outcomes and prognostication of older patients with primary central nervous system lymphoma (PCNSL). We retrospectively analyzed 539 newly\u2010diagnosed PCNSL patients ages \u226560\u2009years across 20 U.S. academic centers. The median age was 70\u2009years (range 60\u201388); at least one geriatric syndrome was present in 46%; the median Cumulative Index Ratings Scale\u2010Geriatrics (CIRS\u2010G) score was 6 (range, 0\u201327); and 36% had impairment in activities of daily living (ADL). The most common induction regimens were high\u2010dose methotrexate (HD\u2010MTX) \u00b1 rituximab; methotrexate, temozolomide, rituximab (MTR); and rituximab, methotrexate, procarbazine, vincristine (R\u2010MPV). Overall, 70% of patients achieved remission, with 14% undergoing consolidative autologous stem cell transplant (ASCT) and 24% receiving maintenance. With 58\u2010month median follow\u2010up, median progression\u2010free survival (PFS) and overall survival (OS) were 17\u2009months (95% CI 13\u201322\u2009months) and 43\u2009months (95% CI 31\u201356\u2009months), respectively. Three\u2010year PFS and OS were highest with MTR (55% and 74%, respectively). With single\u2010agent methotrexate \u00b1 rituximab, 3\u2010year PFS and OS were 30% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.0002) and 47% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.0072). On multivariate analysis, increasing age at diagnosis and Cooperative Oncology Group (ECOG) performance status (PS) was associated with inferior PFS; age, hypoalbuminemia, higher CIRS\u2010G score, and ECOG PS adversely affected OS. Among patients receiving maintenance, 3\u2010year PFS was 65% versus 45% without maintenance (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.02), with 3\u2010year OS of 84% versus 61%, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.0003). Altogether, outcomes in older PCNSL patients appeared optimized with HD\u2010MTX combination induction regimens and maintenance therapy. Furthermore, several prognostic factors, including geriatric measures, were associated with inferior outcomes.\n                  <\/jats:p>","DOI":"10.1002\/ajh.26919","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T15:44:14Z","timestamp":1679759054000},"page":"900-912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Older patients with primary central nervous system lymphoma: Survival and prognostication across 20\n                    <scp>U.S.<\/scp>\n                    cancer centers"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-0376","authenticated-orcid":false,"given":"Kevin A.","family":"David","sequence":"first","affiliation":[{"name":"Rutgers Cancer Institute of New Jersey  New Brunswick New Jersey 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