{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:37:53Z","timestamp":1778848673882,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007361","name":"Fondazione Cassa di Risparmio di Calabria e Lucania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["5\u00d7 1000"],"award-info":[{"award-number":["5\u00d7 1000"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_192439"],"award-info":[{"award-number":["310030_192439"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_169670\/1"],"award-info":[{"award-number":["320030_169670\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["6594\u201020"],"award-info":[{"award-number":["6594\u201020"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1002\/ajh.26927","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T11:44:21Z","timestamp":1681731861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The time to first treatment is an independent predictor of overall survival in chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"98","author":[{"given":"Fortunato","family":"Morabito","sequence":"first","affiliation":[{"name":"Biotechnology Research Unit, Aprigliano, A.O.\/ASP of Cosenza  Cosenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Tripepi","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche, Istituto di Fisiologia Clinica del CNR  Reggio Calabria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-9474","authenticated-orcid":false,"given":"Francesca Romana","family":"Mauro","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology \u201cSapienza\u201d University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-1396","authenticated-orcid":false,"given":"Luca","family":"Laurenti","sequence":"additional","affiliation":[{"name":"Department of Hematology Catholic University Hospital \u201cA. Gemelli\u201d Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-7089","authenticated-orcid":false,"given":"Gianluigi","family":"Reda","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hemato\u2010oncology University of Milano and Hematology CTMO, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7393-1138","authenticated-orcid":false,"given":"Riccardo","family":"Moia","sequence":"additional","affiliation":[{"name":"Division of Haematology, Department of Translational Medicine Universit\u00e0 del Piemonte Orientale  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalgisa","family":"Condoluci","sequence":"additional","affiliation":[{"name":"Oncology Institute of Southern Switzerland and Institute of Oncology Research  Bellinzona Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iolanda","family":"Vincelli","sequence":"additional","affiliation":[{"name":"Hematology Unit of Reggio Calabria  Reggio Calabria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Chiarenza","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia, Ospedale Ferrarotto Universit\u00e0 di Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Vigna","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Onco\u2010hematology, A.O. of Cosenza  Cosenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica Antonia","family":"Martino","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Onco\u2010hematology, A.O. of Cosenza  Cosenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Bruzzese","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Onco\u2010hematology, A.O. of Cosenza  Cosenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Mezzatesta","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche, Istituto di Fisiologia Clinica del CNR  Reggio Calabria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Laureana","sequence":"additional","affiliation":[{"name":"Ematologia, Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli Studi di Roma \u201cTor Vergata,\u201d Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-1101","authenticated-orcid":false,"given":"Giovanna","family":"Cutrona","sequence":"additional","affiliation":[{"name":"UO Molecular Pathology, Ospedale Policlinico San Martino IRCCS  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Di Raimondo","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia, Ospedale Ferrarotto Universit\u00e0 di Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"Fronza","sequence":"additional","affiliation":[{"name":"Mutagenesis and Cancer Prevention Unit, IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3678-5957","authenticated-orcid":false,"given":"Antonella","family":"Zucchetto","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Onco\u2010Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS  Aviano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Bomben","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Onco\u2010Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS  Aviano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca Maria","family":"Rossi","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Onco\u2010Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS  Aviano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Olivieri","sequence":"additional","affiliation":[{"name":"Clinica Ematologica, Centro Trapianti e Terapie Cellulari Azienda Ospedaliera Universitaria S. Maria Misericordia  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Zaja","sequence":"additional","affiliation":[{"name":"Haematology, University of Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Rossi","sequence":"additional","affiliation":[{"name":"Oncology Institute of Southern Switzerland and Institute of Oncology Research  Bellinzona Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[{"name":"Division of Haematology, Department of Translational Medicine Universit\u00e0 del Piemonte Orientale  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ilaria","family":"Del Principe","sequence":"additional","affiliation":[{"name":"Ematologia, Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli Studi di Roma \u201cTor Vergata,\u201d Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiorella","family":"Ilariucci","sequence":"additional","affiliation":[{"name":"Hematology Unit, Azienda USL\u2010IRCCS of Reggio Emilia  Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Del Poeta","sequence":"additional","affiliation":[{"name":"Ematologia, Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli Studi di Roma \u201cTor Vergata,\u201d Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manlio","family":"Ferrarini","sequence":"additional","affiliation":[{"name":"UO Molecular Pathology, Ospedale Policlinico San Martino IRCCS  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-5912","authenticated-orcid":false,"given":"Antonino","family":"Neri","sequence":"additional","affiliation":[{"name":"Scientific Directorate, Azienda USL\u2010IRCCS of Reggio Emilia  Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valter","family":"Gattei","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Onco\u2010Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS  Aviano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5256-0726","authenticated-orcid":false,"given":"Massimo","family":"Gentile","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Onco\u2010hematology, A.O. of Cosenza  Cosenza Italy"},{"name":"Department of Pharmacy, Health and Nutritional Sciences University of Calabria  Rende Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25595"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.4.895.895"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.7534"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001088"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy203"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji237"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30029-8"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24660"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.333"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.06.011"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.26927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T15:57:31Z","timestamp":1692460651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.26927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/ajh.26927"],"URL":"https:\/\/doi.org\/10.1002\/ajh.26927","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]},"assertion":[{"value":"2023-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}